Glymphatic influx and clearance are accelerated by neurovascular coupling: [Inkl. Correction]
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Glymphatic influx and clearance are accelerated by neurovascular coupling : [Inkl. Correction]. / Holstein-rønsbo, Stephanie; Gan, Yiming; Giannetto, Michael J.; Rasmussen, Martin Kaag; Sigurdsson, Björn; Beinlich, Felix Ralf Michael; Rose, Laura; Untiet, Verena; Hablitz, Lauren M.; Kelley, Douglas H.; Nedergaard, Maiken.
In: Nature Neuroscience, Vol. 26, 2023, p. 1042–1053.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Glymphatic influx and clearance are accelerated by neurovascular coupling
T2 - [Inkl. Correction]
AU - Holstein-rønsbo, Stephanie
AU - Gan, Yiming
AU - Giannetto, Michael J.
AU - Rasmussen, Martin Kaag
AU - Sigurdsson, Björn
AU - Beinlich, Felix Ralf Michael
AU - Rose, Laura
AU - Untiet, Verena
AU - Hablitz, Lauren M.
AU - Kelley, Douglas H.
AU - Nedergaard, Maiken
N1 - Correction: 10.1038/s41593-023-01441-1 Link: https://www.nature.com/articles/s41593-023-01441-1
PY - 2023
Y1 - 2023
N2 - Functional hyperemia, also known as neurovascular coupling, is a phenomenon that occurs when neural activity increases local cerebral blood flow. Because all biological activity produces metabolic waste, we here sought to investigate the relationship between functional hyperemia and waste clearance via the glymphatic system. The analysis showed that whisker stimulation increased both glymphatic influx and clearance in the mouse somatosensory cortex with a 1.6-fold increase in periarterial cerebrospinal fluid (CSF) influx velocity in the activated hemisphere. Particle tracking velocimetry revealed a direct coupling between arterial dilation/constriction and periarterial CSF flow velocity. Optogenetic manipulation of vascular smooth muscle cells enhanced glymphatic influx in the absence of neural activation. We propose that impedance pumping allows arterial pulsatility to drive CSF in the same direction as blood flow, and we present a simulation that supports this idea. Thus, functional hyperemia boosts not only the supply of metabolites but also the removal of metabolic waste.
AB - Functional hyperemia, also known as neurovascular coupling, is a phenomenon that occurs when neural activity increases local cerebral blood flow. Because all biological activity produces metabolic waste, we here sought to investigate the relationship between functional hyperemia and waste clearance via the glymphatic system. The analysis showed that whisker stimulation increased both glymphatic influx and clearance in the mouse somatosensory cortex with a 1.6-fold increase in periarterial cerebrospinal fluid (CSF) influx velocity in the activated hemisphere. Particle tracking velocimetry revealed a direct coupling between arterial dilation/constriction and periarterial CSF flow velocity. Optogenetic manipulation of vascular smooth muscle cells enhanced glymphatic influx in the absence of neural activation. We propose that impedance pumping allows arterial pulsatility to drive CSF in the same direction as blood flow, and we present a simulation that supports this idea. Thus, functional hyperemia boosts not only the supply of metabolites but also the removal of metabolic waste.
U2 - 10.1038/s41593-023-01327-2
DO - 10.1038/s41593-023-01327-2
M3 - Journal article
C2 - 37264158
VL - 26
SP - 1042
EP - 1053
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
ER -
ID: 352058202