Genetics of complex diseases: Variations on a theme
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Genetics of complex diseases : Variations on a theme. / Mellerup, Erling; Møller, Gert Lykke; Koefoed, Pernille.
In: Medical Hypotheses, Vol. 78, No. 6, 06.2012, p. 732-4.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genetics of complex diseases
T2 - Variations on a theme
AU - Mellerup, Erling
AU - Møller, Gert Lykke
AU - Koefoed, Pernille
N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.
PY - 2012/6
Y1 - 2012/6
N2 - A complex disease with an inheritable component is polygenic, meaning that several different changes in DNA are the genetic basis for the disease. Such a disease may also be genetically heterogeneous, meaning that independent changes in DNA, i.e. various genotypes, can be the genetic basis for the disease. Each of these genotypes may be characterized by specific combinations of key genetic changes. It is suggested that even if all key changes are found in genes related to the biology of a certain disease, the number of combinations may be so large that the number of different genotypes may be close to the number of patients suffering from the disease. This hypothesis is based on a study of bipolar disorder.
AB - A complex disease with an inheritable component is polygenic, meaning that several different changes in DNA are the genetic basis for the disease. Such a disease may also be genetically heterogeneous, meaning that independent changes in DNA, i.e. various genotypes, can be the genetic basis for the disease. Each of these genotypes may be characterized by specific combinations of key genetic changes. It is suggested that even if all key changes are found in genes related to the biology of a certain disease, the number of combinations may be so large that the number of different genotypes may be close to the number of patients suffering from the disease. This hypothesis is based on a study of bipolar disorder.
U2 - 10.1016/j.mehy.2012.02.019
DO - 10.1016/j.mehy.2012.02.019
M3 - Journal article
C2 - 22424717
VL - 78
SP - 732
EP - 734
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
IS - 6
ER -
ID: 38140598