GABA(B) receptor-mediated modulation of cutaneous input at the cuneate nucleus in anesthetized cats

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

GABA(B) receptor-mediated modulation of cutaneous input at the cuneate nucleus in anesthetized cats. / Soto, C; Martín-Cora, F; Leiras, R; Velo, P; Canedo, A.

In: Neuroscience, Vol. 137, No. 3, 02.2006, p. 1015-30.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Soto, C, Martín-Cora, F, Leiras, R, Velo, P & Canedo, A 2006, 'GABA(B) receptor-mediated modulation of cutaneous input at the cuneate nucleus in anesthetized cats', Neuroscience, vol. 137, no. 3, pp. 1015-30. https://doi.org/10.1016/j.neuroscience.2005.09.026

APA

Soto, C., Martín-Cora, F., Leiras, R., Velo, P., & Canedo, A. (2006). GABA(B) receptor-mediated modulation of cutaneous input at the cuneate nucleus in anesthetized cats. Neuroscience, 137(3), 1015-30. https://doi.org/10.1016/j.neuroscience.2005.09.026

Vancouver

Soto C, Martín-Cora F, Leiras R, Velo P, Canedo A. GABA(B) receptor-mediated modulation of cutaneous input at the cuneate nucleus in anesthetized cats. Neuroscience. 2006 Feb;137(3):1015-30. https://doi.org/10.1016/j.neuroscience.2005.09.026

Author

Soto, C ; Martín-Cora, F ; Leiras, R ; Velo, P ; Canedo, A. / GABA(B) receptor-mediated modulation of cutaneous input at the cuneate nucleus in anesthetized cats. In: Neuroscience. 2006 ; Vol. 137, No. 3. pp. 1015-30.

Bibtex

@article{48970ba11e384ed794fa57aac5a4c1b8,
title = "GABA(B) receptor-mediated modulation of cutaneous input at the cuneate nucleus in anesthetized cats",
abstract = "This study examined the modulatory influence exerted by GABA(B) receptors on the transmission of cutaneous afferent input to cuneate nucleus neurons in anesthetized cats. Electrical stimulation at the center of a receptive field activated cuneate nucleus cells at latencies of < or = 7 ms whereas stimulation at neighboring sites (receptive field edge) increased the response latency. Extracellular recording combined with microiontophoresis demonstrated that GABA(B) receptors are tonically active. Blockade of GABA(B) receptors prolonged sensory-evoked response durations and decreased times of occurrence of successive bursts whereas the agonist baclofen suppressed both these effects. Ejection of baclofen delayed the evoked response from the receptive field edge with respect to the receptive field center response and inhibited responses from the receptive field edge more effectively than responses from the receptive field center. From these results it is concluded that activation of GABA(B) receptors precludes cuneate cells from reaching firing threshold when afferent inputs are weak, spatially modulate cuneate nucleus excitability, play a major role in temporal pattern of discharges, and shape cutaneous receptive fields.",
keywords = "Anesthesia, Animals, Baclofen/pharmacology, Bicuculline/pharmacology, Cats, Depression, Chemical, Electric Stimulation, Evoked Potentials/drug effects, Excitatory Postsynaptic Potentials/physiology, Extracellular Space/physiology, Female, GABA Agonists/pharmacology, GABA Antagonists/pharmacology, Iontophoresis, Male, Medulla Oblongata/physiology, Receptors, GABA-B/drug effects, Skin/innervation, Synaptic Transmission/drug effects",
author = "C Soto and F Mart{\'i}n-Cora and R Leiras and P Velo and A Canedo",
year = "2006",
month = feb,
doi = "10.1016/j.neuroscience.2005.09.026",
language = "English",
volume = "137",
pages = "1015--30",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Pergamon Press",
number = "3",

}

RIS

TY - JOUR

T1 - GABA(B) receptor-mediated modulation of cutaneous input at the cuneate nucleus in anesthetized cats

AU - Soto, C

AU - Martín-Cora, F

AU - Leiras, R

AU - Velo, P

AU - Canedo, A

PY - 2006/2

Y1 - 2006/2

N2 - This study examined the modulatory influence exerted by GABA(B) receptors on the transmission of cutaneous afferent input to cuneate nucleus neurons in anesthetized cats. Electrical stimulation at the center of a receptive field activated cuneate nucleus cells at latencies of < or = 7 ms whereas stimulation at neighboring sites (receptive field edge) increased the response latency. Extracellular recording combined with microiontophoresis demonstrated that GABA(B) receptors are tonically active. Blockade of GABA(B) receptors prolonged sensory-evoked response durations and decreased times of occurrence of successive bursts whereas the agonist baclofen suppressed both these effects. Ejection of baclofen delayed the evoked response from the receptive field edge with respect to the receptive field center response and inhibited responses from the receptive field edge more effectively than responses from the receptive field center. From these results it is concluded that activation of GABA(B) receptors precludes cuneate cells from reaching firing threshold when afferent inputs are weak, spatially modulate cuneate nucleus excitability, play a major role in temporal pattern of discharges, and shape cutaneous receptive fields.

AB - This study examined the modulatory influence exerted by GABA(B) receptors on the transmission of cutaneous afferent input to cuneate nucleus neurons in anesthetized cats. Electrical stimulation at the center of a receptive field activated cuneate nucleus cells at latencies of < or = 7 ms whereas stimulation at neighboring sites (receptive field edge) increased the response latency. Extracellular recording combined with microiontophoresis demonstrated that GABA(B) receptors are tonically active. Blockade of GABA(B) receptors prolonged sensory-evoked response durations and decreased times of occurrence of successive bursts whereas the agonist baclofen suppressed both these effects. Ejection of baclofen delayed the evoked response from the receptive field edge with respect to the receptive field center response and inhibited responses from the receptive field edge more effectively than responses from the receptive field center. From these results it is concluded that activation of GABA(B) receptors precludes cuneate cells from reaching firing threshold when afferent inputs are weak, spatially modulate cuneate nucleus excitability, play a major role in temporal pattern of discharges, and shape cutaneous receptive fields.

KW - Anesthesia

KW - Animals

KW - Baclofen/pharmacology

KW - Bicuculline/pharmacology

KW - Cats

KW - Depression, Chemical

KW - Electric Stimulation

KW - Evoked Potentials/drug effects

KW - Excitatory Postsynaptic Potentials/physiology

KW - Extracellular Space/physiology

KW - Female

KW - GABA Agonists/pharmacology

KW - GABA Antagonists/pharmacology

KW - Iontophoresis

KW - Male

KW - Medulla Oblongata/physiology

KW - Receptors, GABA-B/drug effects

KW - Skin/innervation

KW - Synaptic Transmission/drug effects

U2 - 10.1016/j.neuroscience.2005.09.026

DO - 10.1016/j.neuroscience.2005.09.026

M3 - Journal article

C2 - 16298083

VL - 137

SP - 1015

EP - 1030

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 3

ER -

ID: 249308060