Functional regeneration beyond the glial scar

Research output: Contribution to journal › Review › Research › peer-review

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Functional regeneration beyond the glial scar. / Cregg, Jared M; DePaul, Marc A; Filous, Angela R; Lang, Bradley T; Tran, Amanda; Silver, Jerry.

In: Experimental Neurology, Vol. 253, 03.2014, p. 197-207.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Cregg, JM, DePaul, MA, Filous, AR, Lang, BT, Tran, A & Silver, J 2014, 'Functional regeneration beyond the glial scar', Experimental Neurology, vol. 253, pp. 197-207. https://doi.org/10.1016/j.expneurol.2013.12.024

APA

Cregg, J. M., DePaul, M. A., Filous, A. R., Lang, B. T., Tran, A., & Silver, J. (2014). Functional regeneration beyond the glial scar. Experimental Neurology, 253, 197-207. https://doi.org/10.1016/j.expneurol.2013.12.024

Vancouver

Cregg JM, DePaul MA, Filous AR, Lang BT, Tran A, Silver J. Functional regeneration beyond the glial scar. Experimental Neurology. 2014 Mar;253:197-207. https://doi.org/10.1016/j.expneurol.2013.12.024

Author

Cregg, Jared M ; DePaul, Marc A ; Filous, Angela R ; Lang, Bradley T ; Tran, Amanda ; Silver, Jerry. / Functional regeneration beyond the glial scar. In: Experimental Neurology. 2014 ; Vol. 253. pp. 197-207.

Bibtex

@article{24d09a70876f4b95a8635801b9d12e47,

title = "Functional regeneration beyond the glial scar",

abstract = "Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective tissue elements that contribute to fibrosis. Oligodendrocyte precursor cells proliferate within the lesion and entrap dystrophic axon tips. Here we review evidence that this aggregate scar acts as the major barrier to regeneration of axons after injury. We also consider several exciting new interventions that allow axons to regenerate beyond the glial scar, and discuss the implications of this work for the future of regeneration biology. ",

keywords = "Animals, Cicatrix/pathology, Humans, Nerve Regeneration/physiology, Neuroglia/physiology",

author = "Cregg, {Jared M} and DePaul, {Marc A} and Filous, {Angela R} and Lang, {Bradley T} and Amanda Tran and Jerry Silver",

year = "2014",

month = mar,

doi = "10.1016/j.expneurol.2013.12.024",

language = "English",

volume = "253",

pages = "197--207",

journal = "Experimental Neurology",

issn = "0014-4886",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Functional regeneration beyond the glial scar

AU - Cregg, Jared M

AU - DePaul, Marc A

AU - Filous, Angela R

AU - Lang, Bradley T

AU - Tran, Amanda

AU - Silver, Jerry

PY - 2014/3

Y1 - 2014/3

N2 - Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective tissue elements that contribute to fibrosis. Oligodendrocyte precursor cells proliferate within the lesion and entrap dystrophic axon tips. Here we review evidence that this aggregate scar acts as the major barrier to regeneration of axons after injury. We also consider several exciting new interventions that allow axons to regenerate beyond the glial scar, and discuss the implications of this work for the future of regeneration biology.

AB - Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective tissue elements that contribute to fibrosis. Oligodendrocyte precursor cells proliferate within the lesion and entrap dystrophic axon tips. Here we review evidence that this aggregate scar acts as the major barrier to regeneration of axons after injury. We also consider several exciting new interventions that allow axons to regenerate beyond the glial scar, and discuss the implications of this work for the future of regeneration biology.

KW - Animals

KW - Cicatrix/pathology

KW - Humans

KW - Nerve Regeneration/physiology

KW - Neuroglia/physiology

U2 - 10.1016/j.expneurol.2013.12.024

DO - 10.1016/j.expneurol.2013.12.024

M3 - Review

C2 - 24424280

VL - 253

SP - 197

EP - 207

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

ER -

ID: 248114333

Department of Neuroscience