Functional recruitment of red blood cells to rat brain microcirculation accompanying increased neuronal activity in cerebellar cortex

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Functional recruitment of red blood cells to rat brain microcirculation accompanying increased neuronal activity in cerebellar cortex. / Akgören, Nuran; Lauritzen, Martin.

In: NeuroReport, Vol. 10, No. 16, 01.01.1999, p. 3257-3263.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Akgören, N & Lauritzen, M 1999, 'Functional recruitment of red blood cells to rat brain microcirculation accompanying increased neuronal activity in cerebellar cortex', NeuroReport, vol. 10, no. 16, pp. 3257-3263. https://doi.org/10.1097/00001756-199911080-00002

APA

Akgören, N., & Lauritzen, M. (1999). Functional recruitment of red blood cells to rat brain microcirculation accompanying increased neuronal activity in cerebellar cortex. NeuroReport, 10(16), 3257-3263. https://doi.org/10.1097/00001756-199911080-00002

Vancouver

Akgören N, Lauritzen M. Functional recruitment of red blood cells to rat brain microcirculation accompanying increased neuronal activity in cerebellar cortex. NeuroReport. 1999 Jan 1;10(16):3257-3263. https://doi.org/10.1097/00001756-199911080-00002

Author

Akgören, Nuran ; Lauritzen, Martin. / Functional recruitment of red blood cells to rat brain microcirculation accompanying increased neuronal activity in cerebellar cortex. In: NeuroReport. 1999 ; Vol. 10, No. 16. pp. 3257-3263.

Bibtex

@article{abf4109286404f54802898e3ddd3dab7,
title = "Functional recruitment of red blood cells to rat brain microcirculation accompanying increased neuronal activity in cerebellar cortex",
abstract = "SCANNING laser-Doppler flowmetry (SLDF) combines laser-Doppler flowmetry and laser scanning to provide images of cerebral blood flow (CBF) with high spatial and temporal resolution. We investigated the contribution of single vascular elements to the local increase of CBF accompanying increased neuronal activity in halothane-anesthetized rats. CBF was examined in the cerebellar cortex under control conditions and in response to electrical stimulation of parallel and climbing fibers. At rest, arterioles contributed 9%, venules 1113% and small vessels (< 20μm) 8-14%, while the background constituted 64-72% of the total SLDF signal. During activation the background signal decreased to 55-60% while the signal from arterioles increased to 1112%, from venules to 14-15% and from small vessels to 14-19%. The signal increase in small vessels that did not give any laser-Doppler signal at rest was due to functional recruitment of red blood cells to the capillary bed. We conclude that functional recruitment may be an integral part of the hemodynamic response accompanying neuronal activity.",
keywords = "Brain activation, Cerebellum, Climbing fibers, Microcirculation, Parallel fibers, Scanning laser-Doppler flowmetry",
author = "Nuran Akg{\"o}ren and Martin Lauritzen",
year = "1999",
month = jan,
day = "1",
doi = "10.1097/00001756-199911080-00002",
language = "English",
volume = "10",
pages = "3257--3263",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams & Wilkins",
number = "16",

}

RIS

TY - JOUR

T1 - Functional recruitment of red blood cells to rat brain microcirculation accompanying increased neuronal activity in cerebellar cortex

AU - Akgören, Nuran

AU - Lauritzen, Martin

PY - 1999/1/1

Y1 - 1999/1/1

N2 - SCANNING laser-Doppler flowmetry (SLDF) combines laser-Doppler flowmetry and laser scanning to provide images of cerebral blood flow (CBF) with high spatial and temporal resolution. We investigated the contribution of single vascular elements to the local increase of CBF accompanying increased neuronal activity in halothane-anesthetized rats. CBF was examined in the cerebellar cortex under control conditions and in response to electrical stimulation of parallel and climbing fibers. At rest, arterioles contributed 9%, venules 1113% and small vessels (< 20μm) 8-14%, while the background constituted 64-72% of the total SLDF signal. During activation the background signal decreased to 55-60% while the signal from arterioles increased to 1112%, from venules to 14-15% and from small vessels to 14-19%. The signal increase in small vessels that did not give any laser-Doppler signal at rest was due to functional recruitment of red blood cells to the capillary bed. We conclude that functional recruitment may be an integral part of the hemodynamic response accompanying neuronal activity.

AB - SCANNING laser-Doppler flowmetry (SLDF) combines laser-Doppler flowmetry and laser scanning to provide images of cerebral blood flow (CBF) with high spatial and temporal resolution. We investigated the contribution of single vascular elements to the local increase of CBF accompanying increased neuronal activity in halothane-anesthetized rats. CBF was examined in the cerebellar cortex under control conditions and in response to electrical stimulation of parallel and climbing fibers. At rest, arterioles contributed 9%, venules 1113% and small vessels (< 20μm) 8-14%, while the background constituted 64-72% of the total SLDF signal. During activation the background signal decreased to 55-60% while the signal from arterioles increased to 1112%, from venules to 14-15% and from small vessels to 14-19%. The signal increase in small vessels that did not give any laser-Doppler signal at rest was due to functional recruitment of red blood cells to the capillary bed. We conclude that functional recruitment may be an integral part of the hemodynamic response accompanying neuronal activity.

KW - Brain activation

KW - Cerebellum

KW - Climbing fibers

KW - Microcirculation

KW - Parallel fibers

KW - Scanning laser-Doppler flowmetry

UR - http://www.scopus.com/inward/record.url?scp=0032718406&partnerID=8YFLogxK

U2 - 10.1097/00001756-199911080-00002

DO - 10.1097/00001756-199911080-00002

M3 - Journal article

C2 - 10599830

AN - SCOPUS:0032718406

VL - 10

SP - 3257

EP - 3263

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 16

ER -

ID: 201453679