Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release

Research output: Contribution to journal › Journal article › Research › peer-review

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Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release. / Sigler, Albrecht; Oh, Won Chan; Imig, Cordelia; Altas, Bekir; Kawabe, Hiroshi; Cooper, Benjamin H; Kwon, Hyung-Bae; Rhee, Jeong-Seop; Brose, Nils.

In: Neuron, Vol. 94, No. 2, 19.04.2017, p. 304-311.e4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sigler, A, Oh, WC, Imig, C, Altas, B, Kawabe, H, Cooper, BH, Kwon, H-B, Rhee, J-S & Brose, N 2017, 'Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release', Neuron, vol. 94, no. 2, pp. 304-311.e4. https://doi.org/10.1016/j.neuron.2017.03.029

APA

Sigler, A., Oh, W. C., Imig, C., Altas, B., Kawabe, H., Cooper, B. H., Kwon, H-B., Rhee, J-S., & Brose, N. (2017). Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release. Neuron, 94(2), 304-311.e4. https://doi.org/10.1016/j.neuron.2017.03.029

Vancouver

Sigler A, Oh WC, Imig C, Altas B, Kawabe H, Cooper BH et al. Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release. Neuron. 2017 Apr 19;94(2):304-311.e4. https://doi.org/10.1016/j.neuron.2017.03.029

Author

Sigler, Albrecht ; Oh, Won Chan ; Imig, Cordelia ; Altas, Bekir ; Kawabe, Hiroshi ; Cooper, Benjamin H ; Kwon, Hyung-Bae ; Rhee, Jeong-Seop ; Brose, Nils. / Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release. In: Neuron. 2017 ; Vol. 94, No. 2. pp. 304-311.e4.

Bibtex

@article{6558c38710404b64bb587c6a850b57ee,

title = "Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release",

abstract = "Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. The formation of functional spine synapses is thought to be critically dependent on presynaptic glutamatergic signaling. By analyzing CA1 pyramidal neurons in mutant hippocampal slice cultures that are essentially devoid of presynaptic transmitter release, we demonstrate that the formation and maintenance of dendrites and functional spines are independent of synaptic glutamate release.",

keywords = "Animals, Calcium/metabolism, Dendrites/metabolism, Dendritic Spines/metabolism, Glutamic Acid/metabolism, Hippocampus/metabolism, Mice, Signal Transduction/physiology, Synapses/metabolism",

author = "Albrecht Sigler and Oh, {Won Chan} and Cordelia Imig and Bekir Altas and Hiroshi Kawabe and Cooper, {Benjamin H} and Hyung-Bae Kwon and Jeong-Seop Rhee and Nils Brose",

year = "2017",

month = apr,

day = "19",

doi = "10.1016/j.neuron.2017.03.029",

language = "English",

volume = "94",

pages = "304--311.e4",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "2",

}

RIS

TY - JOUR

T1 - Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release

AU - Sigler, Albrecht

AU - Oh, Won Chan

AU - Imig, Cordelia

AU - Altas, Bekir

AU - Kawabe, Hiroshi

AU - Cooper, Benjamin H

AU - Kwon, Hyung-Bae

AU - Rhee, Jeong-Seop

AU - Brose, Nils

PY - 2017/4/19

Y1 - 2017/4/19

N2 - Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. The formation of functional spine synapses is thought to be critically dependent on presynaptic glutamatergic signaling. By analyzing CA1 pyramidal neurons in mutant hippocampal slice cultures that are essentially devoid of presynaptic transmitter release, we demonstrate that the formation and maintenance of dendrites and functional spines are independent of synaptic glutamate release.

AB - Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. The formation of functional spine synapses is thought to be critically dependent on presynaptic glutamatergic signaling. By analyzing CA1 pyramidal neurons in mutant hippocampal slice cultures that are essentially devoid of presynaptic transmitter release, we demonstrate that the formation and maintenance of dendrites and functional spines are independent of synaptic glutamate release.

KW - Animals

KW - Calcium/metabolism

KW - Dendrites/metabolism

KW - Dendritic Spines/metabolism

KW - Glutamic Acid/metabolism

KW - Hippocampus/metabolism

KW - Mice

KW - Signal Transduction/physiology

KW - Synapses/metabolism

U2 - 10.1016/j.neuron.2017.03.029

DO - 10.1016/j.neuron.2017.03.029

M3 - Journal article

C2 - 28426965

VL - 94

SP - 304-311.e4

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 2

ER -

ID: 237697748

Department of Neuroscience