Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization.

Research output: Contribution to journal › Journal article › Research › peer-review

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Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization. / Blomqvist, G; Gjedde, A; Gutniak, M; Grill, V; Widén, L; Stone-Elander, S; Hellstrand, E.

In: European Journal Of Nuclear Medicine, Vol. 18, No. 10, 1991, p. 834-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Blomqvist, G, Gjedde, A, Gutniak, M, Grill, V, Widén, L, Stone-Elander, S & Hellstrand, E 1991, 'Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization.', European Journal Of Nuclear Medicine, vol. 18, no. 10, pp. 834-7.

APA

Blomqvist, G., Gjedde, A., Gutniak, M., Grill, V., Widén, L., Stone-Elander, S., & Hellstrand, E. (1991). Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization. European Journal Of Nuclear Medicine, 18(10), 834-7.

Vancouver

Blomqvist G, Gjedde A, Gutniak M, Grill V, Widén L, Stone-Elander S et al. Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization. European Journal Of Nuclear Medicine. 1991;18(10):834-7.

Author

Blomqvist, G ; Gjedde, A ; Gutniak, M ; Grill, V ; Widén, L ; Stone-Elander, S ; Hellstrand, E. / Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization. In: European Journal Of Nuclear Medicine. 1991 ; Vol. 18, No. 10. pp. 834-7.

Bibtex

@article{22ff85f0b31511debc73000ea68e967b,
title = "Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization.",
abstract = "The effect of steady-state moderate hypoglycaemia on human brain homeostasis has been studied with positron emission tomography using [U-11C]-D-glucose as tracer. To rule out any effects of insulin, the plasma insulin concentration was maintained at the same level under normo- and hypoglycaemic conditions. Reduction of blood glucose by 55% increased the glucose clearance through the blood-brain barrier by 50% and reduced brain glucose consumption by 40%. Blood flow was not affected. The results are consistent with facilitated transport of glucose from blood to brain in humans. The maximal transport rate of glucose from blood to brain was found to be 62 +/- 19 (mean +/- SEM) mumol hg-1 min-1, and the half-saturation constant was found to be 4.1 +/- 2.3 mM.",
author = "G Blomqvist and A Gjedde and M Gutniak and V Grill and L Wid{\'e}n and S Stone-Elander and E Hellstrand",
year = "1991",
language = "English",
volume = "18",
pages = "834--7",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization.

AU - Blomqvist, G

AU - Gjedde, A

AU - Gutniak, M

AU - Grill, V

AU - Widén, L

AU - Stone-Elander, S

AU - Hellstrand, E

PY - 1991

Y1 - 1991

N2 - The effect of steady-state moderate hypoglycaemia on human brain homeostasis has been studied with positron emission tomography using [U-11C]-D-glucose as tracer. To rule out any effects of insulin, the plasma insulin concentration was maintained at the same level under normo- and hypoglycaemic conditions. Reduction of blood glucose by 55% increased the glucose clearance through the blood-brain barrier by 50% and reduced brain glucose consumption by 40%. Blood flow was not affected. The results are consistent with facilitated transport of glucose from blood to brain in humans. The maximal transport rate of glucose from blood to brain was found to be 62 +/- 19 (mean +/- SEM) mumol hg-1 min-1, and the half-saturation constant was found to be 4.1 +/- 2.3 mM.

AB - The effect of steady-state moderate hypoglycaemia on human brain homeostasis has been studied with positron emission tomography using [U-11C]-D-glucose as tracer. To rule out any effects of insulin, the plasma insulin concentration was maintained at the same level under normo- and hypoglycaemic conditions. Reduction of blood glucose by 55% increased the glucose clearance through the blood-brain barrier by 50% and reduced brain glucose consumption by 40%. Blood flow was not affected. The results are consistent with facilitated transport of glucose from blood to brain in humans. The maximal transport rate of glucose from blood to brain was found to be 62 +/- 19 (mean +/- SEM) mumol hg-1 min-1, and the half-saturation constant was found to be 4.1 +/- 2.3 mM.

M3 - Journal article

C2 - 1743207

VL - 18

SP - 834

EP - 837

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 10

ER -

ID: 14945045