Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Estimating motor unit numbers from a CMAP scan : Repeatability study on three muscles at 15 centres. / Sørensen, D. M.; Bostock, H.; Abrahao, A.; Alaamel, A.; Alaydin, H. C.; Ballegaard, M.; Boran, E.; Cengiz, B.; de Carvalho, M.; Dunker; Fuglsang-Frederiksen, A.; Graffe, C. C.; Jones, K. E.; Kallio, M.; Kalra, S.; Krarup, C.; Krøigård, T.; Liguori, R.; Lupescu, T.; Maitland, S.; Matamala, J. M.; Moldovan, M.; Moreno-Roco, J.; Nilsen, K. B.; Phung, L.; Santos, M. O.; Themistocleous, A. C.; Uysal, H.; Vacchiano, V.; Whittaker, R. G.; Zinman, L.; Tankisi, H.

In: Clinical Neurophysiology, Vol. 151, 2023, p. 92-99.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sørensen, DM, Bostock, H, Abrahao, A, Alaamel, A, Alaydin, HC, Ballegaard, M, Boran, E, Cengiz, B, de Carvalho, M, Dunker, Fuglsang-Frederiksen, A, Graffe, CC, Jones, KE, Kallio, M, Kalra, S, Krarup, C, Krøigård, T, Liguori, R, Lupescu, T, Maitland, S, Matamala, JM, Moldovan, M, Moreno-Roco, J, Nilsen, KB, Phung, L, Santos, MO, Themistocleous, AC, Uysal, H, Vacchiano, V, Whittaker, RG, Zinman, L & Tankisi, H 2023, 'Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres', Clinical Neurophysiology, vol. 151, pp. 92-99. https://doi.org/10.1016/j.clinph.2023.04.008

APA

Sørensen, D. M., Bostock, H., Abrahao, A., Alaamel, A., Alaydin, H. C., Ballegaard, M., Boran, E., Cengiz, B., de Carvalho, M., Dunker, Fuglsang-Frederiksen, A., Graffe, C. C., Jones, K. E., Kallio, M., Kalra, S., Krarup, C., Krøigård, T., Liguori, R., Lupescu, T., ... Tankisi, H. (2023). Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres. Clinical Neurophysiology, 151, 92-99. https://doi.org/10.1016/j.clinph.2023.04.008

Vancouver

Sørensen DM, Bostock H, Abrahao A, Alaamel A, Alaydin HC, Ballegaard M et al. Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres. Clinical Neurophysiology. 2023;151:92-99. https://doi.org/10.1016/j.clinph.2023.04.008

Author

Sørensen, D. M. ; Bostock, H. ; Abrahao, A. ; Alaamel, A. ; Alaydin, H. C. ; Ballegaard, M. ; Boran, E. ; Cengiz, B. ; de Carvalho, M. ; Dunker ; Fuglsang-Frederiksen, A. ; Graffe, C. C. ; Jones, K. E. ; Kallio, M. ; Kalra, S. ; Krarup, C. ; Krøigård, T. ; Liguori, R. ; Lupescu, T. ; Maitland, S. ; Matamala, J. M. ; Moldovan, M. ; Moreno-Roco, J. ; Nilsen, K. B. ; Phung, L. ; Santos, M. O. ; Themistocleous, A. C. ; Uysal, H. ; Vacchiano, V. ; Whittaker, R. G. ; Zinman, L. ; Tankisi, H. / Estimating motor unit numbers from a CMAP scan : Repeatability study on three muscles at 15 centres. In: Clinical Neurophysiology. 2023 ; Vol. 151. pp. 92-99.

Bibtex

@article{87d81829ceb345ec8ca152d1ff7d792b,
title = "Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres",
abstract = "Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.",
keywords = "CMAP Scan, Motor unit number estimation, MScanFit, MUNE, Repeatability",
author = "S{\o}rensen, {D. M.} and H. Bostock and A. Abrahao and A. Alaamel and Alaydin, {H. C.} and M. Ballegaard and E. Boran and B. Cengiz and {de Carvalho}, M. and Dunker and A. Fuglsang-Frederiksen and Graffe, {C. C.} and Jones, {K. E.} and M. Kallio and S. Kalra and C. Krarup and T. Kr{\o}ig{\aa}rd and R. Liguori and T. Lupescu and S. Maitland and Matamala, {J. M.} and M. Moldovan and J. Moreno-Roco and Nilsen, {K. B.} and L. Phung and Santos, {M. O.} and Themistocleous, {A. C.} and H. Uysal and V. Vacchiano and Whittaker, {R. G.} and L. Zinman and H. Tankisi",
note = "Publisher Copyright: {\textcopyright} 2023",
year = "2023",
doi = "10.1016/j.clinph.2023.04.008",
language = "English",
volume = "151",
pages = "92--99",
journal = "Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control",
issn = "1388-2457",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Estimating motor unit numbers from a CMAP scan

T2 - Repeatability study on three muscles at 15 centres

AU - Sørensen, D. M.

AU - Bostock, H.

AU - Abrahao, A.

AU - Alaamel, A.

AU - Alaydin, H. C.

AU - Ballegaard, M.

AU - Boran, E.

AU - Cengiz, B.

AU - de Carvalho, M.

AU - Dunker, null

AU - Fuglsang-Frederiksen, A.

AU - Graffe, C. C.

AU - Jones, K. E.

AU - Kallio, M.

AU - Kalra, S.

AU - Krarup, C.

AU - Krøigård, T.

AU - Liguori, R.

AU - Lupescu, T.

AU - Maitland, S.

AU - Matamala, J. M.

AU - Moldovan, M.

AU - Moreno-Roco, J.

AU - Nilsen, K. B.

AU - Phung, L.

AU - Santos, M. O.

AU - Themistocleous, A. C.

AU - Uysal, H.

AU - Vacchiano, V.

AU - Whittaker, R. G.

AU - Zinman, L.

AU - Tankisi, H.

N1 - Publisher Copyright: © 2023

PY - 2023

Y1 - 2023

N2 - Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.

AB - Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.

KW - CMAP Scan

KW - Motor unit number estimation

KW - MScanFit

KW - MUNE

KW - Repeatability

U2 - 10.1016/j.clinph.2023.04.008

DO - 10.1016/j.clinph.2023.04.008

M3 - Journal article

C2 - 37236129

AN - SCOPUS:85159772140

VL - 151

SP - 92

EP - 99

JO - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control

JF - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control

SN - 1388-2457

ER -

ID: 356178025