Elevated dopamine D1 receptor availability in striatum of Göttingen minipigs after electroconvulsive therapy
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Elevated dopamine D1 receptor availability in striatum of Göttingen minipigs after electroconvulsive therapy. / Landau, Anne M.; Alstrup, Aage Ko; Audrain, Helene; Jakobsen, Steen; Simonsen, Mette; Møller, Arne; Videbech, Poul; Wegener, Gregers; Gjedde, Albert; Doudet, Doris J.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 38, No. 5, 2018, p. 881-887.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Elevated dopamine D1 receptor availability in striatum of Göttingen minipigs after electroconvulsive therapy
AU - Landau, Anne M.
AU - Alstrup, Aage Ko
AU - Audrain, Helene
AU - Jakobsen, Steen
AU - Simonsen, Mette
AU - Møller, Arne
AU - Videbech, Poul
AU - Wegener, Gregers
AU - Gjedde, Albert
AU - Doudet, Doris J
PY - 2018
Y1 - 2018
N2 - Electroconvulsive therapy (ECT), a direct form of brain stimulation, is an effective antidepressant. We hypothesized that the beneficial effects of ECT are mediated by increased dopaminergic neurotransmission, in which the baseline activity of D1 receptors may predict the response to ECT. We established a novel model of brain stimulation in Göttingen minipigs based on the protocol of ECT applied in humans. With positron emission tomography (PET), we determined a measure of dopaminergic neurotransmission with the dopamine D1 receptor antagonist [11C]SCH23390. Seven minipigs were anesthetized and completed PET at baseline, prior to the onset of ECT treatment, and at 24-48 h and 8-10 days after the end of a clinical course of ECT, consisting of 10 ECT sessions over a 3.5-week period. In all pigs, the binding of [11C]SCH23390 to striatal D1 receptors had increased by 24-48 h after ECT, and in most, binding returned towards baseline at 8-10 days. Increased binding was observed in inverse proportion to baseline binding rates. Increased binding to dopamine D1 receptors suggests facilitation of dopaminergic neurotransmission, which may contribute to the therapeutic effects of ECT. Importantly, the baseline binding capacity of D1 receptors predicts the magnitude of increased binding, up to a maximum binding capacity.
AB - Electroconvulsive therapy (ECT), a direct form of brain stimulation, is an effective antidepressant. We hypothesized that the beneficial effects of ECT are mediated by increased dopaminergic neurotransmission, in which the baseline activity of D1 receptors may predict the response to ECT. We established a novel model of brain stimulation in Göttingen minipigs based on the protocol of ECT applied in humans. With positron emission tomography (PET), we determined a measure of dopaminergic neurotransmission with the dopamine D1 receptor antagonist [11C]SCH23390. Seven minipigs were anesthetized and completed PET at baseline, prior to the onset of ECT treatment, and at 24-48 h and 8-10 days after the end of a clinical course of ECT, consisting of 10 ECT sessions over a 3.5-week period. In all pigs, the binding of [11C]SCH23390 to striatal D1 receptors had increased by 24-48 h after ECT, and in most, binding returned towards baseline at 8-10 days. Increased binding was observed in inverse proportion to baseline binding rates. Increased binding to dopamine D1 receptors suggests facilitation of dopaminergic neurotransmission, which may contribute to the therapeutic effects of ECT. Importantly, the baseline binding capacity of D1 receptors predicts the magnitude of increased binding, up to a maximum binding capacity.
U2 - 10.1177/0271678X17705260
DO - 10.1177/0271678X17705260
M3 - Journal article
C2 - 28509598
VL - 38
SP - 881
EP - 887
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 5
ER -
ID: 193895749