Electroencephalographic characterization of seizure activity in the synapsin I/II double knockout mouse
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Electroencephalographic characterization of seizure activity in the synapsin I/II double knockout mouse. / Etholm, Lars; Lindén, Henrik; Eken, Torsten; Heggelund, Paul.
In: Brain Research Journal, Vol. 1383, 06.04.2011, p. 270-88.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Electroencephalographic characterization of seizure activity in the synapsin I/II double knockout mouse
AU - Etholm, Lars
AU - Lindén, Henrik
AU - Eken, Torsten
AU - Heggelund, Paul
N1 - Copyright © 2011 Elsevier B.V. All rights reserved.
PY - 2011/4/6
Y1 - 2011/4/6
N2 - We present a detailed comparison of the behavioral and electrophysiological development of seizure activity in mice genetically depleted of synapsin I and synapsin II (SynDKO mice), based on combined video and surface EEG recordings. SynDKO mice develop handling-induced epileptic seizures at the age of 2months. The seizures show a very regular behavioral pattern, where activity is initially dominated by truncal muscle contractions followed by various myoclonic elements. Whereas seizure behavior goes through clearly defined transitions, cortical activity as reflected by EEG recordings shows a more gradual development with respect to the emergence of different EEG components and the frequency of these components. No EEG pattern was seen to define a particular seizure behavior. However, myoclonic activity was characterized by more regular patterns of combined sharp waves and spikes. Where countable, the number of myoclonic jerks was significantly correlated to the number of such EEG complexes. Furthermore, some EEG recordings revealed epileptic regular discharges without clear behavioral seizure correlates. Our findings suggest that seizure behavior in SynDKO mice is not solely determined by cortical activity but rather reflects interplay between cortical activity and activity in other brain regions.
AB - We present a detailed comparison of the behavioral and electrophysiological development of seizure activity in mice genetically depleted of synapsin I and synapsin II (SynDKO mice), based on combined video and surface EEG recordings. SynDKO mice develop handling-induced epileptic seizures at the age of 2months. The seizures show a very regular behavioral pattern, where activity is initially dominated by truncal muscle contractions followed by various myoclonic elements. Whereas seizure behavior goes through clearly defined transitions, cortical activity as reflected by EEG recordings shows a more gradual development with respect to the emergence of different EEG components and the frequency of these components. No EEG pattern was seen to define a particular seizure behavior. However, myoclonic activity was characterized by more regular patterns of combined sharp waves and spikes. Where countable, the number of myoclonic jerks was significantly correlated to the number of such EEG complexes. Furthermore, some EEG recordings revealed epileptic regular discharges without clear behavioral seizure correlates. Our findings suggest that seizure behavior in SynDKO mice is not solely determined by cortical activity but rather reflects interplay between cortical activity and activity in other brain regions.
KW - Animals
KW - Behavior, Animal
KW - Brain
KW - Disease Models, Animal
KW - Electroencephalography
KW - Epilepsy
KW - Mice
KW - Mice, Knockout
KW - Seizures
KW - Synapsins
U2 - 10.1016/j.brainres.2011.01.070
DO - 10.1016/j.brainres.2011.01.070
M3 - Journal article
C2 - 21281619
VL - 1383
SP - 270
EP - 288
JO - Brain Research Journal
JF - Brain Research Journal
SN - 1935-2875
ER -
ID: 50204799