Effects of vasopressin on blood-brain transfer of methionine in dogs.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effects of vasopressin on blood-brain transfer of methionine in dogs. / Brust, P; Shaya, E K; Jeffries, K J; Dannals, R F; Ravert, H T; Wilson, A A; Conti, P S; Wagner, H N; Gjedde, A; Ermisch, A.

In: Journal of Neurochemistry, Vol. 59, No. 4, 1992, p. 1421-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brust, P, Shaya, EK, Jeffries, KJ, Dannals, RF, Ravert, HT, Wilson, AA, Conti, PS, Wagner, HN, Gjedde, A & Ermisch, A 1992, 'Effects of vasopressin on blood-brain transfer of methionine in dogs.', Journal of Neurochemistry, vol. 59, no. 4, pp. 1421-9.

APA

Brust, P., Shaya, E. K., Jeffries, K. J., Dannals, R. F., Ravert, H. T., Wilson, A. A., Conti, P. S., Wagner, H. N., Gjedde, A., & Ermisch, A. (1992). Effects of vasopressin on blood-brain transfer of methionine in dogs. Journal of Neurochemistry, 59(4), 1421-9.

Vancouver

Brust P, Shaya EK, Jeffries KJ, Dannals RF, Ravert HT, Wilson AA et al. Effects of vasopressin on blood-brain transfer of methionine in dogs. Journal of Neurochemistry. 1992;59(4):1421-9.

Author

Brust, P ; Shaya, E K ; Jeffries, K J ; Dannals, R F ; Ravert, H T ; Wilson, A A ; Conti, P S ; Wagner, H N ; Gjedde, A ; Ermisch, A. / Effects of vasopressin on blood-brain transfer of methionine in dogs. In: Journal of Neurochemistry. 1992 ; Vol. 59, No. 4. pp. 1421-9.

Bibtex

@article{edf7ee60b31411debc73000ea68e967b,
title = "Effects of vasopressin on blood-brain transfer of methionine in dogs.",
abstract = "We used a simplified probe detection system for positron-emitting radionuclides in order to measure blood-brain barrier transport of amino acids in anesthetized dogs. Plasma and brain time-activity curves were recorded after intravenous bolus injection of L-[11C]methionine before and after administration of 1 microgram of vasopressin. Three-compartment models with three or four transfer coefficients were used to derive the kinetics of L-[11C]methionine uptake in brain. The blood-brain clearance of the tracer (K1) was 0.075 ml ml-1 min-1 before and 0.041 ml ml-1 min-1 after injection of vasopressin. The partition volume and the initial distribution (plasma) volume of methionine were unchanged and within the expected limits. The net accumulation rate of methionine (K), estimated by both the four-parameter (kinetic) and three-parameter (graphic) approaches, decreased after vasopressin injection in all six studies.",
author = "P Brust and Shaya, {E K} and Jeffries, {K J} and Dannals, {R F} and Ravert, {H T} and Wilson, {A A} and Conti, {P S} and Wagner, {H N} and A Gjedde and A Ermisch",
year = "1992",
language = "English",
volume = "59",
pages = "1421--9",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of vasopressin on blood-brain transfer of methionine in dogs.

AU - Brust, P

AU - Shaya, E K

AU - Jeffries, K J

AU - Dannals, R F

AU - Ravert, H T

AU - Wilson, A A

AU - Conti, P S

AU - Wagner, H N

AU - Gjedde, A

AU - Ermisch, A

PY - 1992

Y1 - 1992

N2 - We used a simplified probe detection system for positron-emitting radionuclides in order to measure blood-brain barrier transport of amino acids in anesthetized dogs. Plasma and brain time-activity curves were recorded after intravenous bolus injection of L-[11C]methionine before and after administration of 1 microgram of vasopressin. Three-compartment models with three or four transfer coefficients were used to derive the kinetics of L-[11C]methionine uptake in brain. The blood-brain clearance of the tracer (K1) was 0.075 ml ml-1 min-1 before and 0.041 ml ml-1 min-1 after injection of vasopressin. The partition volume and the initial distribution (plasma) volume of methionine were unchanged and within the expected limits. The net accumulation rate of methionine (K), estimated by both the four-parameter (kinetic) and three-parameter (graphic) approaches, decreased after vasopressin injection in all six studies.

AB - We used a simplified probe detection system for positron-emitting radionuclides in order to measure blood-brain barrier transport of amino acids in anesthetized dogs. Plasma and brain time-activity curves were recorded after intravenous bolus injection of L-[11C]methionine before and after administration of 1 microgram of vasopressin. Three-compartment models with three or four transfer coefficients were used to derive the kinetics of L-[11C]methionine uptake in brain. The blood-brain clearance of the tracer (K1) was 0.075 ml ml-1 min-1 before and 0.041 ml ml-1 min-1 after injection of vasopressin. The partition volume and the initial distribution (plasma) volume of methionine were unchanged and within the expected limits. The net accumulation rate of methionine (K), estimated by both the four-parameter (kinetic) and three-parameter (graphic) approaches, decreased after vasopressin injection in all six studies.

M3 - Journal article

C2 - 1402892

VL - 59

SP - 1421

EP - 1429

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

IS - 4

ER -

ID: 14942493