Effects of the pyrethroid insecticide, deltamethrin, on respiratory modulated hypoglossal motoneurons in a brain stem slice from newborn mice
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Effects of the pyrethroid insecticide, deltamethrin, on respiratory modulated hypoglossal motoneurons in a brain stem slice from newborn mice. / Rekling, J C; Theophilidis, G.
In: Neuroscience Letters, Vol. 198, No. 3, 1995, p. 189-92.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of the pyrethroid insecticide, deltamethrin, on respiratory modulated hypoglossal motoneurons in a brain stem slice from newborn mice
AU - Rekling, J C
AU - Theophilidis, G
N1 - Keywords: Animals; Animals, Newborn; Brain Stem; Hypoglossal Nerve; Insecticides; Membrane Potentials; Mice; Mice, Inbred Strains; Motor Neurons; Nitriles; Pyrethrins
PY - 1995
Y1 - 1995
N2 - We have studied the action of deltamethrin on respiratory modulated hypoglossal motoneurons in a brain stem slice from newborn mice. Deltamethrin depolarized the hypoglossal motoneurons, increased the background synaptic noise and reduced the frequency and amplitude of current elicited action potentials. Deltamethrin transiently increased the frequency of the respiratory rhythm. Inspiratory potentials in hypoglossal motoneurons were decreased in amplitude and increased in duration. In conclusion, deltamethrin perturbs the respiratory output from the hypoglossal nucleus through postsynaptic actions on hypoglossal motoneurons and by affecting the inspiratory synaptic drive.
AB - We have studied the action of deltamethrin on respiratory modulated hypoglossal motoneurons in a brain stem slice from newborn mice. Deltamethrin depolarized the hypoglossal motoneurons, increased the background synaptic noise and reduced the frequency and amplitude of current elicited action potentials. Deltamethrin transiently increased the frequency of the respiratory rhythm. Inspiratory potentials in hypoglossal motoneurons were decreased in amplitude and increased in duration. In conclusion, deltamethrin perturbs the respiratory output from the hypoglossal nucleus through postsynaptic actions on hypoglossal motoneurons and by affecting the inspiratory synaptic drive.
M3 - Journal article
C2 - 8552318
VL - 198
SP - 189
EP - 192
JO - Neuroscience letters. Supplement
JF - Neuroscience letters. Supplement
SN - 0167-6253
IS - 3
ER -
ID: 9256054