Effects of gadolinium (Gd) and a Gd-based contrast agent (GBCA) on early life stages of zebrafish (Danio rerio)
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Effects of gadolinium (Gd) and a Gd-based contrast agent (GBCA) on early life stages of zebrafish (Danio rerio). / Piarulli, Stefania; Riedel, Juliane A.; Fossum, Frida N.; Kermen, Florence; Hansen, Bjørn Henrik; Kvæstad, Bjarne; Olsvik, Pål A.; Farkas, Julia.
In: Chemosphere, Vol. 350, 140950, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of gadolinium (Gd) and a Gd-based contrast agent (GBCA) on early life stages of zebrafish (Danio rerio)
AU - Piarulli, Stefania
AU - Riedel, Juliane A.
AU - Fossum, Frida N.
AU - Kermen, Florence
AU - Hansen, Bjørn Henrik
AU - Kvæstad, Bjarne
AU - Olsvik, Pål A.
AU - Farkas, Julia
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2024
Y1 - 2024
N2 - Gadolinium (Gd) is one of the rare earth elements (REY) and is widely used in magnetic resonance imaging (MRI) contrast agents. Anthropogenic Gd enrichment has frequently been found in wastewater treatment plant effluents in industrialised countries, rising concerns regarding effects on aquatic biota. This study investigates the acute toxicity and sublethal effects of Gd in two forms, as inorganic salt (GdCl3) and as Gd-based contrast agent (GBCA), on early life stages of zebrafish (Danio rerio). Nominal exposure concentrations ranged from 3 to 3000 μg L−1, with an exposure duration of 96 h. None of the two tested compounds were acutely toxic to embryos and larvae. Similarly, we did not observe any effects on larval development and locomotive behaviour. However, we found significant changes in the brain activity of larvae exposed to the highest concentrations of GdCl3 and the GBCA. Our findings show that Gd can have sublethal effects on developing fish at lower concentrations than reported previously, highlighting the necessity of investigating the long-term fate and effects of GBCAs released into the aquatic environment.
AB - Gadolinium (Gd) is one of the rare earth elements (REY) and is widely used in magnetic resonance imaging (MRI) contrast agents. Anthropogenic Gd enrichment has frequently been found in wastewater treatment plant effluents in industrialised countries, rising concerns regarding effects on aquatic biota. This study investigates the acute toxicity and sublethal effects of Gd in two forms, as inorganic salt (GdCl3) and as Gd-based contrast agent (GBCA), on early life stages of zebrafish (Danio rerio). Nominal exposure concentrations ranged from 3 to 3000 μg L−1, with an exposure duration of 96 h. None of the two tested compounds were acutely toxic to embryos and larvae. Similarly, we did not observe any effects on larval development and locomotive behaviour. However, we found significant changes in the brain activity of larvae exposed to the highest concentrations of GdCl3 and the GBCA. Our findings show that Gd can have sublethal effects on developing fish at lower concentrations than reported previously, highlighting the necessity of investigating the long-term fate and effects of GBCAs released into the aquatic environment.
KW - Ecotoxicity
KW - Embryotoxicity
KW - Fish
KW - Neurotoxicity
KW - Rare earth elements
KW - REE
U2 - 10.1016/j.chemosphere.2023.140950
DO - 10.1016/j.chemosphere.2023.140950
M3 - Journal article
C2 - 38114019
AN - SCOPUS:85181840105
VL - 350
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
M1 - 140950
ER -
ID: 380150056