Effects of acute spinalization on neurons of postural networks
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Effects of acute spinalization on neurons of postural networks. / Zelenin, Pavel V; Lyalka, Vladimir F; Hsu, Li-Ju; Orlovsky, Grigori N; Deliagina, Tatiana G.
In: Scientific Reports, Vol. 6, 27372, 15.06.2016.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Effects of acute spinalization on neurons of postural networks
AU - Zelenin, Pavel V
AU - Lyalka, Vladimir F
AU - Hsu, Li-Ju
AU - Orlovsky, Grigori N
AU - Deliagina, Tatiana G
PY - 2016/6/15
Y1 - 2016/6/15
N2 - Postural limb reflexes (PLRs) represent a substantial component of postural corrections. Spinalization results in loss of postural functions, including disappearance of PLRs. The aim of the present study was to characterize the effects of acute spinalization on two populations of spinal neurons (F and E) mediating PLRs, which we characterized previously. For this purpose, in decerebrate rabbits spinalized at T12, responses of interneurons from L5 to stimulation causing PLRs before spinalization, were recorded. The results were compared to control data obtained in our previous study. We found that spinalization affected the distribution of F- and E-neurons across the spinal grey matter, caused a significant decrease in their activity, as well as disturbances in processing of posture-related sensory inputs. A two-fold decrease in the proportion of F-neurons in the intermediate grey matter was observed. Location of populations of F- and E-neurons exhibiting significant decrease in their activity was determined. A dramatic decrease of the efficacy of sensory input from the ipsilateral limb to F-neurons, and from the contralateral limb to E-neurons was found. These changes in operation of postural networks underlie the loss of postural control after spinalization, and represent a starting point for the development of spasticity.
AB - Postural limb reflexes (PLRs) represent a substantial component of postural corrections. Spinalization results in loss of postural functions, including disappearance of PLRs. The aim of the present study was to characterize the effects of acute spinalization on two populations of spinal neurons (F and E) mediating PLRs, which we characterized previously. For this purpose, in decerebrate rabbits spinalized at T12, responses of interneurons from L5 to stimulation causing PLRs before spinalization, were recorded. The results were compared to control data obtained in our previous study. We found that spinalization affected the distribution of F- and E-neurons across the spinal grey matter, caused a significant decrease in their activity, as well as disturbances in processing of posture-related sensory inputs. A two-fold decrease in the proportion of F-neurons in the intermediate grey matter was observed. Location of populations of F- and E-neurons exhibiting significant decrease in their activity was determined. A dramatic decrease of the efficacy of sensory input from the ipsilateral limb to F-neurons, and from the contralateral limb to E-neurons was found. These changes in operation of postural networks underlie the loss of postural control after spinalization, and represent a starting point for the development of spasticity.
KW - Animals
KW - Extremities/physiology
KW - Gray Matter/physiology
KW - Interneurons/physiology
KW - Neurons/physiology
KW - Postural Balance/physiology
KW - Posture/physiology
KW - Rabbits
KW - Reflex/physiology
KW - Spinal Cord/physiology
KW - Spinal Cord Injuries/physiopathology
U2 - 10.1038/srep27372
DO - 10.1038/srep27372
M3 - Journal article
C2 - 27302149
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 27372
ER -
ID: 248187139