Dynamic changes in brain glucose and lactate in pericontusional areas of the human cerebral cortex, monitored with rapid sampling on-line microdialysis: Relationship with depolarisation-like events
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Dynamic changes in brain glucose and lactate in pericontusional areas of the human cerebral cortex, monitored with rapid sampling on-line microdialysis : Relationship with depolarisation-like events. / Parkin, Mark C.; Hopwood, Sarah E.; Jones, Deborah A.; Hashemi, Parastoo; Landolt, Hans; Fabricius, Martin; Lauritzen, Martin; Boutelle, Martyn G.; Strong, Anthony J.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 25, No. 3, 01.03.2005, p. 402-413.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dynamic changes in brain glucose and lactate in pericontusional areas of the human cerebral cortex, monitored with rapid sampling on-line microdialysis
T2 - Relationship with depolarisation-like events
AU - Parkin, Mark C.
AU - Hopwood, Sarah E.
AU - Jones, Deborah A.
AU - Hashemi, Parastoo
AU - Landolt, Hans
AU - Fabricius, Martin
AU - Lauritzen, Martin
AU - Boutelle, Martyn G.
AU - Strong, Anthony J.
PY - 2005/3/1
Y1 - 2005/3/1
N2 - The pathophysiology of peri-lesion boundary zones in acute brain injury is highly dynamic, and it is now clear that spreading-depression-like events occur frequently in areas of cerebral cortex adjacent to contusions in the injured human brain. An automated method to assay microdialysate from peri-lesion cerebral cortex in 11 patients with intracranial haematomas requiring surgery was used. Perfusate (2 μL/min) flowed directly into a flow-injection system for assay of glucose and lactate at intervals typically of 30 secs each. Four channels of electrocorticogram (ECoG) were recorded from a subdural strip adjacent to the catheter. Several patterns of change in metabolites were identified in different time domains. Overall, the number of transient lactate events was significantly correlated with the number of glucose events (r 2 = 0.48, P = 0.027, n = 10). Progressive reduction in dialysate glucose was very closely correlated with the aggregate number of ECoG events (r2 = 0.76, P = 0.0004, n = 11). It is proposed that the recently documented adverse impact of low dialysate glucose on clinical outcome may be because of recurrent, spontaneous spreading-depression-like events in the perilesion cortex.
AB - The pathophysiology of peri-lesion boundary zones in acute brain injury is highly dynamic, and it is now clear that spreading-depression-like events occur frequently in areas of cerebral cortex adjacent to contusions in the injured human brain. An automated method to assay microdialysate from peri-lesion cerebral cortex in 11 patients with intracranial haematomas requiring surgery was used. Perfusate (2 μL/min) flowed directly into a flow-injection system for assay of glucose and lactate at intervals typically of 30 secs each. Four channels of electrocorticogram (ECoG) were recorded from a subdural strip adjacent to the catheter. Several patterns of change in metabolites were identified in different time domains. Overall, the number of transient lactate events was significantly correlated with the number of glucose events (r 2 = 0.48, P = 0.027, n = 10). Progressive reduction in dialysate glucose was very closely correlated with the aggregate number of ECoG events (r2 = 0.76, P = 0.0004, n = 11). It is proposed that the recently documented adverse impact of low dialysate glucose on clinical outcome may be because of recurrent, spontaneous spreading-depression-like events in the perilesion cortex.
KW - Brain-trauma
KW - Electroencephalogram
KW - Glucose
KW - Human
KW - Lactate
KW - Microdialysis
KW - Spreading-cortical-depression
UR - http://www.scopus.com/inward/record.url?scp=14644406225&partnerID=8YFLogxK
U2 - 10.1038/sj.jcbfm.9600051
DO - 10.1038/sj.jcbfm.9600051
M3 - Journal article
C2 - 15703701
AN - SCOPUS:14644406225
VL - 25
SP - 402
EP - 413
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 3
ER -
ID: 200873530