Dual function of the choroid plexus: Cerebrospinal fluid production and control of brain ion homeostasis
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Dual function of the choroid plexus : Cerebrospinal fluid production and control of brain ion homeostasis. / MacAulay, Nanna; Toft-Bertelsen, Trine L.
In: Cell Calcium, Vol. 116, 102797, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dual function of the choroid plexus
T2 - Cerebrospinal fluid production and control of brain ion homeostasis
AU - MacAulay, Nanna
AU - Toft-Bertelsen, Trine L.
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - The choroid plexus is a small monolayered epithelium located in the brain ventricles and serves to secrete the cerebrospinal fluid (CSF) that envelops the brain and fills the central ventricles. The CSF secretion is sustained with a concerted effort of a range of membrane transporters located in a polarized fashion in this tissue. Prominent amongst these are the Na+/K+-ATPase, the Na+,K+,2Cl− cotransporter (NKCC1), and several HCO3− transporters, which together support the net transepithelial transport of the major electrolytes, Na+ and Cl−, and thus drive the CSF secretion. The choroid plexus, in addition, serves an important role in keeping the CSF K+ concentration at a level compatible with normal brain function. The choroid plexus Na+/K+-ATPase represents a key factor in the barrier-mediated control of the CSF K+ homeostasis, as it increases its K+ uptake activity when faced with elevated extracellular K+ ([K+]o). In certain developmental or pathological conditions, the NKCC1 may revert its net transport direction to contribute to CSF K+ homeostasis. The choroid plexus ion transport machinery thus serves dual, yet interconnected, functions with its contribution to electrolyte and fluid secretion in combination with its control of brain K+ levels.
AB - The choroid plexus is a small monolayered epithelium located in the brain ventricles and serves to secrete the cerebrospinal fluid (CSF) that envelops the brain and fills the central ventricles. The CSF secretion is sustained with a concerted effort of a range of membrane transporters located in a polarized fashion in this tissue. Prominent amongst these are the Na+/K+-ATPase, the Na+,K+,2Cl− cotransporter (NKCC1), and several HCO3− transporters, which together support the net transepithelial transport of the major electrolytes, Na+ and Cl−, and thus drive the CSF secretion. The choroid plexus, in addition, serves an important role in keeping the CSF K+ concentration at a level compatible with normal brain function. The choroid plexus Na+/K+-ATPase represents a key factor in the barrier-mediated control of the CSF K+ homeostasis, as it increases its K+ uptake activity when faced with elevated extracellular K+ ([K+]o). In certain developmental or pathological conditions, the NKCC1 may revert its net transport direction to contribute to CSF K+ homeostasis. The choroid plexus ion transport machinery thus serves dual, yet interconnected, functions with its contribution to electrolyte and fluid secretion in combination with its control of brain K+ levels.
KW - Cerebrospinal fluid
KW - Choroid plexus
KW - Ionic gradients
KW - K homeostasis
KW - Membrane transport
KW - Na/K-ATPase
U2 - 10.1016/j.ceca.2023.102797
DO - 10.1016/j.ceca.2023.102797
M3 - Journal article
C2 - 37801806
AN - SCOPUS:85173253199
VL - 116
JO - Cell Calcium
JF - Cell Calcium
SN - 0143-4160
M1 - 102797
ER -
ID: 370478255