Drug-induced optic neuropathy

Department of Neuroscience

Drug-induced optic neuropathy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Drug-induced optic neuropathy. / Horwitz, Anna; Horwitz, Henrik.

In: Adverse Drug Reaction Bulletin, Vol. 334, No. 1, 2022, p. 1295-1298.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Horwitz, A & Horwitz, H 2022, 'Drug-induced optic neuropathy', Adverse Drug Reaction Bulletin, vol. 334, no. 1, pp. 1295-1298. https://doi.org/10.1097/FAD.0000000000000062

APA

Horwitz, A., & Horwitz, H. (2022). Drug-induced optic neuropathy. Adverse Drug Reaction Bulletin, 334(1), 1295-1298. https://doi.org/10.1097/FAD.0000000000000062

Vancouver

Horwitz A, Horwitz H. Drug-induced optic neuropathy. Adverse Drug Reaction Bulletin. 2022;334(1):1295-1298. https://doi.org/10.1097/FAD.0000000000000062

Author

Horwitz, Anna ; Horwitz, Henrik. / Drug-induced optic neuropathy. In: Adverse Drug Reaction Bulletin. 2022 ; Vol. 334, No. 1. pp. 1295-1298.

Bibtex

@article{ad25f3183eec4f0d849c276ae7e1fd6e,

title = "Drug-induced optic neuropathy",

abstract = "Drug-induced optic neuropathy is an understudied subject, and most of the evidence is based on case-reports. Amiodarone, ciprofloxacin, disulfiram, and sildenafil have been associated with optic neuropathy and their use is relatively prevalent. We therefore set out to investigate the strength of this association. In this nationwide cohort, we identified all incident users of the four drugs studied during the period 1 January 1999 to 31 December 2018. We then investigated their incidence of optic neuropathy in the year prior to prescription and in the year following We found that the risk of being diagnosed with optic neuropathy was 2.27 [95% confidence interval (1.29-4.00)] higher times during amiodarone therapy than in the year prior to prescription, but for the three other drugs we found no certain association. This study revealed a weak association between optic neuropathy and amiodarone; however, we were unable to confirm any association with ciprofloxacin, sildenafil, and disulfiram.",

author = "Anna Horwitz and Henrik Horwitz",

year = "2022",

doi = "10.1097/FAD.0000000000000062",

language = "English",

volume = "334",

pages = "1295--1298",

journal = "Adverse Drug Reaction Bulletin",

issn = "0044-6394",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

RIS

TY - JOUR

T1 - Drug-induced optic neuropathy

AU - Horwitz, Anna

AU - Horwitz, Henrik

PY - 2022

Y1 - 2022

N2 - Drug-induced optic neuropathy is an understudied subject, and most of the evidence is based on case-reports. Amiodarone, ciprofloxacin, disulfiram, and sildenafil have been associated with optic neuropathy and their use is relatively prevalent. We therefore set out to investigate the strength of this association. In this nationwide cohort, we identified all incident users of the four drugs studied during the period 1 January 1999 to 31 December 2018. We then investigated their incidence of optic neuropathy in the year prior to prescription and in the year following We found that the risk of being diagnosed with optic neuropathy was 2.27 [95% confidence interval (1.29-4.00)] higher times during amiodarone therapy than in the year prior to prescription, but for the three other drugs we found no certain association. This study revealed a weak association between optic neuropathy and amiodarone; however, we were unable to confirm any association with ciprofloxacin, sildenafil, and disulfiram.

AB - Drug-induced optic neuropathy is an understudied subject, and most of the evidence is based on case-reports. Amiodarone, ciprofloxacin, disulfiram, and sildenafil have been associated with optic neuropathy and their use is relatively prevalent. We therefore set out to investigate the strength of this association. In this nationwide cohort, we identified all incident users of the four drugs studied during the period 1 January 1999 to 31 December 2018. We then investigated their incidence of optic neuropathy in the year prior to prescription and in the year following We found that the risk of being diagnosed with optic neuropathy was 2.27 [95% confidence interval (1.29-4.00)] higher times during amiodarone therapy than in the year prior to prescription, but for the three other drugs we found no certain association. This study revealed a weak association between optic neuropathy and amiodarone; however, we were unable to confirm any association with ciprofloxacin, sildenafil, and disulfiram.

U2 - 10.1097/FAD.0000000000000062

DO - 10.1097/FAD.0000000000000062

M3 - Journal article

AN - SCOPUS:85134409792

VL - 334

SP - 1295

EP - 1298

JO - Adverse Drug Reaction Bulletin

JF - Adverse Drug Reaction Bulletin

SN - 0044-6394

IS - 1

ER -

ID: 315250703