Dorsal root potential produced by a TTX-insensitive micro-circuitry in the turtle spinal cord

Research output: Contribution to journal › Journal article › Research › peer-review

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Dorsal root potential produced by a TTX-insensitive micro-circuitry in the turtle spinal cord. / Russo, R E; Delgado-Lezama, R; Hounsgaard, J.

In: Journal of Physiology, Vol. 528 Pt 1, 01.10.2000, p. 115-22.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Russo, RE, Delgado-Lezama, R & Hounsgaard, J 2000, 'Dorsal root potential produced by a TTX-insensitive micro-circuitry in the turtle spinal cord', Journal of Physiology, vol. 528 Pt 1, pp. 115-22.

APA

Russo, R. E., Delgado-Lezama, R., & Hounsgaard, J. (2000). Dorsal root potential produced by a TTX-insensitive micro-circuitry in the turtle spinal cord. Journal of Physiology, 528 Pt 1, 115-22.

Vancouver

Russo RE, Delgado-Lezama R, Hounsgaard J. Dorsal root potential produced by a TTX-insensitive micro-circuitry in the turtle spinal cord. Journal of Physiology. 2000 Oct 1;528 Pt 1:115-22.

Author

Russo, R E ; Delgado-Lezama, R ; Hounsgaard, J. / Dorsal root potential produced by a TTX-insensitive micro-circuitry in the turtle spinal cord. In: Journal of Physiology. 2000 ; Vol. 528 Pt 1. pp. 115-22.

Bibtex

@article{617ab6b090a14651bb05a891cdd25a77,
title = "Dorsal root potential produced by a TTX-insensitive micro-circuitry in the turtle spinal cord",
abstract = "1, The mechanisms underlying the dorsal root potential (DRP) were studied in transverse slices of turtle spinal cord. DRPs were evoked by stimulating one filament in a dorsal root and were recorded from another such filament. 2. The DRP evoked at supramaximal stimulus intensity was reduced but not eliminated after blockade of GABAA receptors. The remaining component was eliminated by blocking NMDA and AMPA receptors. 3. The DRP was reduced but not eliminated after blockade of AMPA receptors. The early component of the remaining DRP was dependent on GABAA receptors and the residual component on NMDA receptors. 4. The DRP was reduced but not eliminated by TTX. GABAA, NMDA and AMPA receptors contributed to the generation of the TTX-insensitive DRP. The early component of the DRP in the presence of TTX depended on GABAA receptor activation, and the late component mainly on the activation of NMDA receptors. 5. Our results show that part of the DRP is generated by a TTX-resistant, probably non-spiking micro-circuit with separate components mediated by GABA and glutamate.",
keywords = "6-Cyano-7-nitroquinoxaline-2,3-dione, Animals, Bicuculline, Evoked Potentials, Excitatory Amino Acid Antagonists, GABA Antagonists, GABA-A Receptor Antagonists, Nerve Net, Reaction Time, Receptors, AMPA, Receptors, N-Methyl-D-Aspartate, Spinal Cord, Spinal Nerve Roots, Tetrodotoxin, Turtles",
author = "Russo, {R E} and R Delgado-Lezama and J Hounsgaard",
year = "2000",
month = oct,
day = "1",
language = "English",
volume = "528 Pt 1",
pages = "115--22",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Dorsal root potential produced by a TTX-insensitive micro-circuitry in the turtle spinal cord

AU - Russo, R E

AU - Delgado-Lezama, R

AU - Hounsgaard, J

PY - 2000/10/1

Y1 - 2000/10/1

N2 - 1, The mechanisms underlying the dorsal root potential (DRP) were studied in transverse slices of turtle spinal cord. DRPs were evoked by stimulating one filament in a dorsal root and were recorded from another such filament. 2. The DRP evoked at supramaximal stimulus intensity was reduced but not eliminated after blockade of GABAA receptors. The remaining component was eliminated by blocking NMDA and AMPA receptors. 3. The DRP was reduced but not eliminated after blockade of AMPA receptors. The early component of the remaining DRP was dependent on GABAA receptors and the residual component on NMDA receptors. 4. The DRP was reduced but not eliminated by TTX. GABAA, NMDA and AMPA receptors contributed to the generation of the TTX-insensitive DRP. The early component of the DRP in the presence of TTX depended on GABAA receptor activation, and the late component mainly on the activation of NMDA receptors. 5. Our results show that part of the DRP is generated by a TTX-resistant, probably non-spiking micro-circuit with separate components mediated by GABA and glutamate.

AB - 1, The mechanisms underlying the dorsal root potential (DRP) were studied in transverse slices of turtle spinal cord. DRPs were evoked by stimulating one filament in a dorsal root and were recorded from another such filament. 2. The DRP evoked at supramaximal stimulus intensity was reduced but not eliminated after blockade of GABAA receptors. The remaining component was eliminated by blocking NMDA and AMPA receptors. 3. The DRP was reduced but not eliminated after blockade of AMPA receptors. The early component of the remaining DRP was dependent on GABAA receptors and the residual component on NMDA receptors. 4. The DRP was reduced but not eliminated by TTX. GABAA, NMDA and AMPA receptors contributed to the generation of the TTX-insensitive DRP. The early component of the DRP in the presence of TTX depended on GABAA receptor activation, and the late component mainly on the activation of NMDA receptors. 5. Our results show that part of the DRP is generated by a TTX-resistant, probably non-spiking micro-circuit with separate components mediated by GABA and glutamate.

KW - 6-Cyano-7-nitroquinoxaline-2,3-dione

KW - Animals

KW - Bicuculline

KW - Evoked Potentials

KW - Excitatory Amino Acid Antagonists

KW - GABA Antagonists

KW - GABA-A Receptor Antagonists

KW - Nerve Net

KW - Reaction Time

KW - Receptors, AMPA

KW - Receptors, N-Methyl-D-Aspartate

KW - Spinal Cord

KW - Spinal Nerve Roots

KW - Tetrodotoxin

KW - Turtles

M3 - Journal article

C2 - 11018110

VL - 528 Pt 1

SP - 115

EP - 122

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

ER -

ID: 33731445