Dopa decarboxylase activity of the living human brain.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dopa decarboxylase activity of the living human brain. / Gjedde, A; Reith, J; Dyve, S; Léger, G; Guttman, M; Diksic, M; Evans, A; Kuwabara, H.

In: Proceedings of the National Academy of Science of the United States of America, Vol. 88, No. 7, 1991, p. 2721-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjedde, A, Reith, J, Dyve, S, Léger, G, Guttman, M, Diksic, M, Evans, A & Kuwabara, H 1991, 'Dopa decarboxylase activity of the living human brain.', Proceedings of the National Academy of Science of the United States of America, vol. 88, no. 7, pp. 2721-5.

APA

Gjedde, A., Reith, J., Dyve, S., Léger, G., Guttman, M., Diksic, M., Evans, A., & Kuwabara, H. (1991). Dopa decarboxylase activity of the living human brain. Proceedings of the National Academy of Science of the United States of America, 88(7), 2721-5.

Vancouver

Gjedde A, Reith J, Dyve S, Léger G, Guttman M, Diksic M et al. Dopa decarboxylase activity of the living human brain. Proceedings of the National Academy of Science of the United States of America. 1991;88(7):2721-5.

Author

Gjedde, A ; Reith, J ; Dyve, S ; Léger, G ; Guttman, M ; Diksic, M ; Evans, A ; Kuwabara, H. / Dopa decarboxylase activity of the living human brain. In: Proceedings of the National Academy of Science of the United States of America. 1991 ; Vol. 88, No. 7. pp. 2721-5.

Bibtex

@article{2b2cb950b31511debc73000ea68e967b,
title = "Dopa decarboxylase activity of the living human brain.",
abstract = "Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). We measured regional dopa decarboxylase activity in brains of six healthy volunteers with 6-[18F]fluoro-L-dopa and positron emission tomography. We calculated the enzyme activity, relative to its Km, with a kinetic model that yielded the relative rate of conversion of 6-[18F]fluoro-L-dopa to [18F]fluorodopamine. Regional values of relative dopa decarboxylase activity ranged from nil in occipital cortex to 1.9 h-1 in caudate nucleus and putamen, in agreement with values obtained in vitro.",
author = "A Gjedde and J Reith and S Dyve and G L{\'e}ger and M Guttman and M Diksic and A Evans and H Kuwabara",
year = "1991",
language = "English",
volume = "88",
pages = "2721--5",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "7",

}

RIS

TY - JOUR

T1 - Dopa decarboxylase activity of the living human brain.

AU - Gjedde, A

AU - Reith, J

AU - Dyve, S

AU - Léger, G

AU - Guttman, M

AU - Diksic, M

AU - Evans, A

AU - Kuwabara, H

PY - 1991

Y1 - 1991

N2 - Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). We measured regional dopa decarboxylase activity in brains of six healthy volunteers with 6-[18F]fluoro-L-dopa and positron emission tomography. We calculated the enzyme activity, relative to its Km, with a kinetic model that yielded the relative rate of conversion of 6-[18F]fluoro-L-dopa to [18F]fluorodopamine. Regional values of relative dopa decarboxylase activity ranged from nil in occipital cortex to 1.9 h-1 in caudate nucleus and putamen, in agreement with values obtained in vitro.

AB - Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). We measured regional dopa decarboxylase activity in brains of six healthy volunteers with 6-[18F]fluoro-L-dopa and positron emission tomography. We calculated the enzyme activity, relative to its Km, with a kinetic model that yielded the relative rate of conversion of 6-[18F]fluoro-L-dopa to [18F]fluorodopamine. Regional values of relative dopa decarboxylase activity ranged from nil in occipital cortex to 1.9 h-1 in caudate nucleus and putamen, in agreement with values obtained in vitro.

M3 - Journal article

C2 - 1688340

VL - 88

SP - 2721

EP - 2725

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 7

ER -

ID: 14945452