Difusión simultánea de inositol y manitol en cerebro de rata.

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The diffusion of both inositol and mannitol has been determined simultaneously by the integral bolus method in rat brain. The permeability constant (Kin) of inositol averaged 0.27 +/- 0.02 ml X (100 g)-1 X min-1 or 4 X 10(-7) cm X s-1 at a cerebral capillary surface area of 100 cm2 x g-1. The permeability of mannitol was 0.08 +/- 0.01 ml X (100 g)-1. min-1 or 1 X 10(-7) cm X s-1. Neither glucose nor galactose affected the inositol permeability. Hypoglycemia increased somewhat the Km value for mannitol. The basal ganglia showed an increase Km for both substrates as compared with those obtained for cortex, temporal and parietal tissues.
Translated title of the contributionSimultaneous diffusion of inositol and mannitol in the rat brain
Original languageSpanish
JournalRevista española de fisiología
Issue number3
Pages (from-to)317-9
Number of pages2
Publication statusPublished - 1982
Externally publishedYes

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