Development and regulation of response properties in spinal cord motoneurons

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Standard

Development and regulation of response properties in spinal cord motoneurons. / Perrier, J F; Hounsgaard, J.

In: Brain Research Bulletin, Vol. 53, No. 5, 15.11.2000, p. 529-35.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Perrier, JF & Hounsgaard, J 2000, 'Development and regulation of response properties in spinal cord motoneurons', Brain Research Bulletin, vol. 53, no. 5, pp. 529-35.

APA

Perrier, J. F., & Hounsgaard, J. (2000). Development and regulation of response properties in spinal cord motoneurons. Brain Research Bulletin, 53(5), 529-35.

Vancouver

Perrier JF, Hounsgaard J. Development and regulation of response properties in spinal cord motoneurons. Brain Research Bulletin. 2000 Nov 15;53(5):529-35.

Author

Perrier, J F ; Hounsgaard, J. / Development and regulation of response properties in spinal cord motoneurons. In: Brain Research Bulletin. 2000 ; Vol. 53, No. 5. pp. 529-35.

Bibtex

@article{d4b2480475364100abcfa94931b8accd,
title = "Development and regulation of response properties in spinal cord motoneurons",
abstract = "The intrinsic response properties of spinal motoneurons determine how converging premotor neuronal input is translated into the final motor command transmitted to muscles. From the patchy data available it seems that these properties and their underlying currents are highly conserved in terrestrial vertebrates in terms of both phylogeny and ontogeny. Spinal motoneurons in adults are remarkably similar in many respects ranging from the resting membrane potential to pacemaker properties. Apart from the axolotls, spinal motoneurons from all species investigated have latent intrinsic response properties mediated by L-type Ca2+ channels. This mature phenotype is reached gradually during development through phases in which A-type potassium channels and T-type calcium channels are transiently expressed. The intrinsic response properties of mature spinal motoneurons are subject to short-term adjustments via metabotropic synaptic regulation of the properties of voltage-sensitive ion channels. Recent findings also suggest that regulation of channel expression may contribute to long-term changes in intrinsic response properties of motoneurons.",
keywords = "Action Potentials, Animals, Anterior Horn Cells, Calcium Channels, L-Type, Calcium Channels, T-Type, Vertebrates",
author = "Perrier, {J F} and J Hounsgaard",
year = "2000",
month = nov,
day = "15",
language = "English",
volume = "53",
pages = "529--35",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Development and regulation of response properties in spinal cord motoneurons

AU - Perrier, J F

AU - Hounsgaard, J

PY - 2000/11/15

Y1 - 2000/11/15

N2 - The intrinsic response properties of spinal motoneurons determine how converging premotor neuronal input is translated into the final motor command transmitted to muscles. From the patchy data available it seems that these properties and their underlying currents are highly conserved in terrestrial vertebrates in terms of both phylogeny and ontogeny. Spinal motoneurons in adults are remarkably similar in many respects ranging from the resting membrane potential to pacemaker properties. Apart from the axolotls, spinal motoneurons from all species investigated have latent intrinsic response properties mediated by L-type Ca2+ channels. This mature phenotype is reached gradually during development through phases in which A-type potassium channels and T-type calcium channels are transiently expressed. The intrinsic response properties of mature spinal motoneurons are subject to short-term adjustments via metabotropic synaptic regulation of the properties of voltage-sensitive ion channels. Recent findings also suggest that regulation of channel expression may contribute to long-term changes in intrinsic response properties of motoneurons.

AB - The intrinsic response properties of spinal motoneurons determine how converging premotor neuronal input is translated into the final motor command transmitted to muscles. From the patchy data available it seems that these properties and their underlying currents are highly conserved in terrestrial vertebrates in terms of both phylogeny and ontogeny. Spinal motoneurons in adults are remarkably similar in many respects ranging from the resting membrane potential to pacemaker properties. Apart from the axolotls, spinal motoneurons from all species investigated have latent intrinsic response properties mediated by L-type Ca2+ channels. This mature phenotype is reached gradually during development through phases in which A-type potassium channels and T-type calcium channels are transiently expressed. The intrinsic response properties of mature spinal motoneurons are subject to short-term adjustments via metabotropic synaptic regulation of the properties of voltage-sensitive ion channels. Recent findings also suggest that regulation of channel expression may contribute to long-term changes in intrinsic response properties of motoneurons.

KW - Action Potentials

KW - Animals

KW - Anterior Horn Cells

KW - Calcium Channels, L-Type

KW - Calcium Channels, T-Type

KW - Vertebrates

M3 - Journal article

C2 - 11165788

VL - 53

SP - 529

EP - 535

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

IS - 5

ER -

ID: 33731418