Dense distributed processing in a hindlimb scratch motor network
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Dense distributed processing in a hindlimb scratch motor network. / Guzulaitis, Robertas; Hounsgaard, Jørn Dybkjær.
In: Journal of Neuroscience, Vol. 34, No. 32, 06.08.2014, p. 10756-10764.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dense distributed processing in a hindlimb scratch motor network
AU - Guzulaitis, Robertas
AU - Hounsgaard, Jørn Dybkjær
PY - 2014/8/6
Y1 - 2014/8/6
N2 - In reduced preparations, hindlimb movements can be generated by a minimal network of neurons in the limb innervating spinal segments. The network of neurons that generates real movements is less well delineated. In an ex vivo carapace-spinal cord preparation from adult turtles (Trachemys scripta elegans), we show that ventral horn interneurons in mid-thoracic spinal segments are functionally integrated in the hindlimb scratch network. First, mid-thoracic interneurons receive intense synaptic input during scratching and behave like neurons in the hindlimb enlargement. Second, some mid-thoracic interneurons activated during scratching project descending axons toward the hindlimb enlargement. Third, elimination of mid-thoracic segments leads to a weakening of scratch rhythmicity. We conclude that densely innervated interneurons in mid-thoracic segments contribute to hindlimb scratching and may be part of a distributed motor network that secures motor coherence.
AB - In reduced preparations, hindlimb movements can be generated by a minimal network of neurons in the limb innervating spinal segments. The network of neurons that generates real movements is less well delineated. In an ex vivo carapace-spinal cord preparation from adult turtles (Trachemys scripta elegans), we show that ventral horn interneurons in mid-thoracic spinal segments are functionally integrated in the hindlimb scratch network. First, mid-thoracic interneurons receive intense synaptic input during scratching and behave like neurons in the hindlimb enlargement. Second, some mid-thoracic interneurons activated during scratching project descending axons toward the hindlimb enlargement. Third, elimination of mid-thoracic segments leads to a weakening of scratch rhythmicity. We conclude that densely innervated interneurons in mid-thoracic segments contribute to hindlimb scratching and may be part of a distributed motor network that secures motor coherence.
U2 - 10.1523/JNEUROSCI.1079-14.2014
DO - 10.1523/JNEUROSCI.1079-14.2014
M3 - Journal article
C2 - 25100606
VL - 34
SP - 10756
EP - 10764
JO - The Journal of neuroscience : the official journal of the Society for Neuroscience
JF - The Journal of neuroscience : the official journal of the Society for Neuroscience
SN - 0270-6474
IS - 32
ER -
ID: 138803434