Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis)

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Standard

Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis). / Darusman, H S; Call, J; Sajuthi, D; Schapiro, S J; Gjedde, A; Kalliokoski, O; Hau, J.

In: Primates, Vol. 55, No. 2, 04.2014, p. 259-67.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Darusman, HS, Call, J, Sajuthi, D, Schapiro, SJ, Gjedde, A, Kalliokoski, O & Hau, J 2014, 'Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis)', Primates, vol. 55, no. 2, pp. 259-67. https://doi.org/10.1007/s10329-013-0397-8

APA

Darusman, H. S., Call, J., Sajuthi, D., Schapiro, S. J., Gjedde, A., Kalliokoski, O., & Hau, J. (2014). Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis). Primates, 55(2), 259-67. https://doi.org/10.1007/s10329-013-0397-8

Vancouver

Darusman HS, Call J, Sajuthi D, Schapiro SJ, Gjedde A, Kalliokoski O et al. Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis). Primates. 2014 Apr;55(2):259-67. https://doi.org/10.1007/s10329-013-0397-8

Author

Darusman, H S ; Call, J ; Sajuthi, D ; Schapiro, S J ; Gjedde, A ; Kalliokoski, O ; Hau, J. / Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis). In: Primates. 2014 ; Vol. 55, No. 2. pp. 259-67.

Bibtex

@article{6b333853376f4bb699b96fe54f6fa718,
title = "Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis)",
abstract = "We compared delayed response task performance in young, middle-aged, and old cynomolgus monkeys using three memory tests that have been used with non-human primates. Eighteen cynomolgus monkeys-6 young (4-9 years), 6 middle-aged (10-19 years), and 6 old (above 20 years)-were tested. In general, the old monkeys scored significantly worse than did the animals in the two other age groups. Longer delays between stimulus presentation and response increased the performance differences between the old and younger monkeys. The old monkeys in particular showed signs of impaired visuo-spatial memory and deteriorated memory consolidation and executive functioning. These results add to the body of evidence supporting the utility of Macaca fascicularis in studies of cognition and as a potential translational model for age-associated memory impairment/dementia-related disorders.",
author = "Darusman, {H S} and J Call and D Sajuthi and Schapiro, {S J} and A Gjedde and O Kalliokoski and J Hau",
year = "2014",
month = apr,
doi = "10.1007/s10329-013-0397-8",
language = "English",
volume = "55",
pages = "259--67",
journal = "Primates",
issn = "0032-8332",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis)

AU - Darusman, H S

AU - Call, J

AU - Sajuthi, D

AU - Schapiro, S J

AU - Gjedde, A

AU - Kalliokoski, O

AU - Hau, J

PY - 2014/4

Y1 - 2014/4

N2 - We compared delayed response task performance in young, middle-aged, and old cynomolgus monkeys using three memory tests that have been used with non-human primates. Eighteen cynomolgus monkeys-6 young (4-9 years), 6 middle-aged (10-19 years), and 6 old (above 20 years)-were tested. In general, the old monkeys scored significantly worse than did the animals in the two other age groups. Longer delays between stimulus presentation and response increased the performance differences between the old and younger monkeys. The old monkeys in particular showed signs of impaired visuo-spatial memory and deteriorated memory consolidation and executive functioning. These results add to the body of evidence supporting the utility of Macaca fascicularis in studies of cognition and as a potential translational model for age-associated memory impairment/dementia-related disorders.

AB - We compared delayed response task performance in young, middle-aged, and old cynomolgus monkeys using three memory tests that have been used with non-human primates. Eighteen cynomolgus monkeys-6 young (4-9 years), 6 middle-aged (10-19 years), and 6 old (above 20 years)-were tested. In general, the old monkeys scored significantly worse than did the animals in the two other age groups. Longer delays between stimulus presentation and response increased the performance differences between the old and younger monkeys. The old monkeys in particular showed signs of impaired visuo-spatial memory and deteriorated memory consolidation and executive functioning. These results add to the body of evidence supporting the utility of Macaca fascicularis in studies of cognition and as a potential translational model for age-associated memory impairment/dementia-related disorders.

U2 - 10.1007/s10329-013-0397-8

DO - 10.1007/s10329-013-0397-8

M3 - Journal article

C2 - 24248474

VL - 55

SP - 259

EP - 267

JO - Primates

JF - Primates

SN - 0032-8332

IS - 2

ER -

ID: 120196560