CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus: a systematic review
Research output: Contribution to journal › Review › Research › peer-review
Standard
CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus : a systematic review. / Ben-Shoshan, Shai David; Lolansen, Sara Diana; Mathiesen, Tiit Illimar; MacAulay, Nanna.
In: Acta Neurochirurgica, Vol. 165, 2023, p. 3271-3287.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus
T2 - a systematic review
AU - Ben-Shoshan, Shai David
AU - Lolansen, Sara Diana
AU - Mathiesen, Tiit Illimar
AU - MacAulay, Nanna
N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
PY - 2023
Y1 - 2023
N2 - Background: The molecular mechanisms underlying development of posthemorrhagic hydrocephalus (PHH) remain elusive. The aim of this systematic review was to evaluate existing literature on increased CSF secretion and impaired CSF absorption as pathogenic contributors to CSF accumulation in neonatal and adult PHH. Methods: The systematic review was conducted in accordance with the PRISMA guidelines. Relevant studies published before March 11th, 2023, were identified from PubMed and reference lists. Studies were screened for eligibility using predefined inclusion and exclusion criteria. Data from eligible studies were extracted and potential sources of bias were evaluated. Results: Nineteen studies quantified CSF production rates and/or CSF absorption capacity in human patients with PHH or animals with experimentally induced PHH. Increased CSF production was reported as early as 24 h and as late as 28 days post ictus in six out of eight studies quantifying CSF production rates in animals with experimentally induced PHH. Impaired CSF absorption was reported in all four studies quantifying CSF absorption capacity in human patients with PHH and in seven out of nine studies quantifying CSF absorption capacity in animals with experimentally induced PHH. Impaired CSF absorption was reported as early as 30 min and as late as 10 months post ictus. Conclusions: The pathological CSF accumulation in PHH likely arises from a combination of increased CSF secretion and impaired CSF absorption, which may manifest at different time scales following a hemorrhagic event. Emergent evidence on increased CSF secretion by the choroid plexus may herald a paradigm shift in our understanding of PHH.
AB - Background: The molecular mechanisms underlying development of posthemorrhagic hydrocephalus (PHH) remain elusive. The aim of this systematic review was to evaluate existing literature on increased CSF secretion and impaired CSF absorption as pathogenic contributors to CSF accumulation in neonatal and adult PHH. Methods: The systematic review was conducted in accordance with the PRISMA guidelines. Relevant studies published before March 11th, 2023, were identified from PubMed and reference lists. Studies were screened for eligibility using predefined inclusion and exclusion criteria. Data from eligible studies were extracted and potential sources of bias were evaluated. Results: Nineteen studies quantified CSF production rates and/or CSF absorption capacity in human patients with PHH or animals with experimentally induced PHH. Increased CSF production was reported as early as 24 h and as late as 28 days post ictus in six out of eight studies quantifying CSF production rates in animals with experimentally induced PHH. Impaired CSF absorption was reported in all four studies quantifying CSF absorption capacity in human patients with PHH and in seven out of nine studies quantifying CSF absorption capacity in animals with experimentally induced PHH. Impaired CSF absorption was reported as early as 30 min and as late as 10 months post ictus. Conclusions: The pathological CSF accumulation in PHH likely arises from a combination of increased CSF secretion and impaired CSF absorption, which may manifest at different time scales following a hemorrhagic event. Emergent evidence on increased CSF secretion by the choroid plexus may herald a paradigm shift in our understanding of PHH.
KW - Cerebrospinal fluid
KW - Cerebrospinal fluid absorption
KW - Cerebrospinal fluid production
KW - Choroid plexus
KW - Inflammation
KW - Posthemorrhagic hydrocephalus
U2 - 10.1007/s00701-023-05746-9
DO - 10.1007/s00701-023-05746-9
M3 - Review
C2 - 37642688
AN - SCOPUS:85169003444
VL - 165
SP - 3271
EP - 3287
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
SN - 0001-6268
ER -
ID: 366301072