Cortical responses to promontorial stimulation in postlingual deafness
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Cortical responses to promontorial stimulation in postlingual deafness. / Mortensen, Malene Vejby; Madsen, Stig; Gjedde, Albert.
In: Hearing Research, Vol. 209, No. 1-2, 2005, p. 32-41.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cortical responses to promontorial stimulation in postlingual deafness
AU - Mortensen, Malene Vejby
AU - Madsen, Stig
AU - Gjedde, Albert
PY - 2005
Y1 - 2005
N2 - Electrical stimulation with a transtympanic electrode on the promontory of the middle ear allows the tasks of gap detection and temporal difference limen (TDL) to be carried out by both normally hearing and deaf subjects. Previous neuroimaging of normally hearing subjects revealed a region in the right posterior temporal lobe that is crucial to duration discrimination. The present study tested the hypothesis that postlingually deaf subjects recruit this area when they make subtle temporal discriminations. Fourteen postlingually deaf adult cochlear implant candidates were stimulated in the ear chosen for implantation. Altered cerebral activity was recorded with positron emission tomography as incremental 15-O-labelled water uptake. On stimulation with tone bursts, we found bilateral activity close to the primary auditory cortex in all subjects. However, subjects performing well on the TDL task demonstrated right-lateralized fronto-temporal and left-lateralized temporal activity in the respective TDL and gap-detection tasks, while subjects who failed to detect duration differences of less than 200 ms in the TDL discrimination task only had frontal and occipital rather than temporal lobe activation. We conclude that the ability to involve the right posterior temporal region is important to duration discrimination. This ability can be evaluated pre-operatively.
AB - Electrical stimulation with a transtympanic electrode on the promontory of the middle ear allows the tasks of gap detection and temporal difference limen (TDL) to be carried out by both normally hearing and deaf subjects. Previous neuroimaging of normally hearing subjects revealed a region in the right posterior temporal lobe that is crucial to duration discrimination. The present study tested the hypothesis that postlingually deaf subjects recruit this area when they make subtle temporal discriminations. Fourteen postlingually deaf adult cochlear implant candidates were stimulated in the ear chosen for implantation. Altered cerebral activity was recorded with positron emission tomography as incremental 15-O-labelled water uptake. On stimulation with tone bursts, we found bilateral activity close to the primary auditory cortex in all subjects. However, subjects performing well on the TDL task demonstrated right-lateralized fronto-temporal and left-lateralized temporal activity in the respective TDL and gap-detection tasks, while subjects who failed to detect duration differences of less than 200 ms in the TDL discrimination task only had frontal and occipital rather than temporal lobe activation. We conclude that the ability to involve the right posterior temporal region is important to duration discrimination. This ability can be evaluated pre-operatively.
U2 - 10.1016/j.heares.2005.05.011
DO - 10.1016/j.heares.2005.05.011
M3 - Journal article
C2 - 16098697
VL - 209
SP - 32
EP - 41
JO - Hearing Research
JF - Hearing Research
SN - 0378-5955
IS - 1-2
ER -
ID: 14943709