Combinations of genetic data in a study of oral cancer

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Standard

Combinations of genetic data in a study of oral cancer. / Mellerup, Erling Thyge; Møller, Gert Lykke; Mondal, Pinaki; Roychoudhury, Susanta.

In: Genes & Cancer, Vol. 6, No. 9-10, 09.2015, p. 422-427.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mellerup, ET, Møller, GL, Mondal, P & Roychoudhury, S 2015, 'Combinations of genetic data in a study of oral cancer', Genes & Cancer, vol. 6, no. 9-10, pp. 422-427. https://doi.org/10.18632/genesandcancer.79

APA

Mellerup, E. T., Møller, G. L., Mondal, P., & Roychoudhury, S. (2015). Combinations of genetic data in a study of oral cancer. Genes & Cancer, 6(9-10), 422-427. https://doi.org/10.18632/genesandcancer.79

Vancouver

Mellerup ET, Møller GL, Mondal P, Roychoudhury S. Combinations of genetic data in a study of oral cancer. Genes & Cancer. 2015 Sep;6(9-10):422-427. https://doi.org/10.18632/genesandcancer.79

Author

Mellerup, Erling Thyge ; Møller, Gert Lykke ; Mondal, Pinaki ; Roychoudhury, Susanta. / Combinations of genetic data in a study of oral cancer. In: Genes & Cancer. 2015 ; Vol. 6, No. 9-10. pp. 422-427.

Bibtex

@article{104e68ef6db648638d4cf4da56e2c0c4,
title = "Combinations of genetic data in a study of oral cancer",
abstract = "In the single locus strategy a number of genetic variants are analyzed, in order to find variants that are distributed significantly different between controls and patients. A supplementary strategy is to analyze combinations of genetic variants. A combination that is the genetic basis for a polygenic disorder will not occur in in control persons genetically unrelated to patients, so the strategy is to analyze combinations of genetic variants present exclusively in patients. In a previous study of oral cancer and leukoplakia 325 SNPs were analyzed. This study has been supplemented with an analysis of combinations of two SNP genotypes from among the 325 SNPs. Two clusters of combinations containing 95 patient specific combinations were significantly associated with oral cancer or leukoplakia. Of 373 patients with oral cancer 205 patients had a number of these 95 combinations in their genome, whereas none of 535 control persons had any of these combinations in their genome. ",
author = "Mellerup, {Erling Thyge} and M{\o}ller, {Gert Lykke} and Pinaki Mondal and Susanta Roychoudhury",
year = "2015",
month = sep,
doi = "10.18632/genesandcancer.79",
language = "English",
volume = "6",
pages = "422--427",
journal = "Genes and Cancer",
issn = "1947-6019",
publisher = "Impact Journals LLC",
number = "9-10",

}

RIS

TY - JOUR

T1 - Combinations of genetic data in a study of oral cancer

AU - Mellerup, Erling Thyge

AU - Møller, Gert Lykke

AU - Mondal, Pinaki

AU - Roychoudhury, Susanta

PY - 2015/9

Y1 - 2015/9

N2 - In the single locus strategy a number of genetic variants are analyzed, in order to find variants that are distributed significantly different between controls and patients. A supplementary strategy is to analyze combinations of genetic variants. A combination that is the genetic basis for a polygenic disorder will not occur in in control persons genetically unrelated to patients, so the strategy is to analyze combinations of genetic variants present exclusively in patients. In a previous study of oral cancer and leukoplakia 325 SNPs were analyzed. This study has been supplemented with an analysis of combinations of two SNP genotypes from among the 325 SNPs. Two clusters of combinations containing 95 patient specific combinations were significantly associated with oral cancer or leukoplakia. Of 373 patients with oral cancer 205 patients had a number of these 95 combinations in their genome, whereas none of 535 control persons had any of these combinations in their genome.

AB - In the single locus strategy a number of genetic variants are analyzed, in order to find variants that are distributed significantly different between controls and patients. A supplementary strategy is to analyze combinations of genetic variants. A combination that is the genetic basis for a polygenic disorder will not occur in in control persons genetically unrelated to patients, so the strategy is to analyze combinations of genetic variants present exclusively in patients. In a previous study of oral cancer and leukoplakia 325 SNPs were analyzed. This study has been supplemented with an analysis of combinations of two SNP genotypes from among the 325 SNPs. Two clusters of combinations containing 95 patient specific combinations were significantly associated with oral cancer or leukoplakia. Of 373 patients with oral cancer 205 patients had a number of these 95 combinations in their genome, whereas none of 535 control persons had any of these combinations in their genome.

U2 - 10.18632/genesandcancer.79

DO - 10.18632/genesandcancer.79

M3 - Journal article

C2 - 26622944

VL - 6

SP - 422

EP - 427

JO - Genes and Cancer

JF - Genes and Cancer

SN - 1947-6019

IS - 9-10

ER -

ID: 147930402