Coffee drinking enhances the analgesic effect of cigarette smoking
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Coffee drinking enhances the analgesic effect of cigarette smoking. / Nastase, Anca; Ioan, Silvia; Braga, Radu I; Zagrean, Leon; Moldovan, Mihai.
In: NeuroReport, Vol. 18, No. 9, 2007, p. 921-4.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Coffee drinking enhances the analgesic effect of cigarette smoking
AU - Nastase, Anca
AU - Ioan, Silvia
AU - Braga, Radu I
AU - Zagrean, Leon
AU - Moldovan, Mihai
N1 - Keywords: Adult; Analgesia; Blood Pressure; Coffee; Cold Temperature; Drug Synergism; Female; Humans; Male; Pain; Pain Measurement; Pain Threshold; Pressure; Smoking; Substance Withdrawal Syndrome
PY - 2007
Y1 - 2007
N2 - Nicotine (from cigarette smoke) and caffeine (from coffee) have analgesic effects in humans and experimental animals. We investigated the combined effects of coffee drinking and cigarette smoking on pain experience in a group of moderate nicotine-dependent, coffee drinking, young smokers. Pain threshold and pain tolerance were measured during cold pressor test following the habitual nocturnal deprivation of smoking and coffee drinking. Smoking increased pain threshold and pain tolerance in both men and women. Coffee drinking, at a dose that had no independent effect, doubled the increase in pain threshold induced by smoking. The effect could not be explained by a cumulative raise in blood pressure. Our data suggest that caffeine enhances the analgesic effect of nicotine.
AB - Nicotine (from cigarette smoke) and caffeine (from coffee) have analgesic effects in humans and experimental animals. We investigated the combined effects of coffee drinking and cigarette smoking on pain experience in a group of moderate nicotine-dependent, coffee drinking, young smokers. Pain threshold and pain tolerance were measured during cold pressor test following the habitual nocturnal deprivation of smoking and coffee drinking. Smoking increased pain threshold and pain tolerance in both men and women. Coffee drinking, at a dose that had no independent effect, doubled the increase in pain threshold induced by smoking. The effect could not be explained by a cumulative raise in blood pressure. Our data suggest that caffeine enhances the analgesic effect of nicotine.
U2 - 10.1097/WNR.0b013e32811d6d0d
DO - 10.1097/WNR.0b013e32811d6d0d
M3 - Journal article
C2 - 17515802
VL - 18
SP - 921
EP - 924
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 9
ER -
ID: 21662058