Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research
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Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research. / Jørgensen, Søren H; Fitzpatrick, Ciarán Martin; Gether, Ulrik; Woldbye, David P D; Sørensen, Andreas T.
In: Basic & Clinical Pharmacology & Toxicology, Vol. 121, No. 5, 11.2017, p. 373-381.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research
AU - Jørgensen, Søren H
AU - Fitzpatrick, Ciarán Martin
AU - Gether, Ulrik
AU - Woldbye, David P D
AU - Sørensen, Andreas T
N1 - © 2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
PY - 2017/11
Y1 - 2017/11
N2 - Attention is a fundamental cognitive process involved in nearly all aspects of life. Abnormal attentional control is a symptom of many neurological disorders, most notably recognized in ADHD (attention deficit hyperactivity disorder). Although attentional performance and its malfunction has been a major area of investigation, it has proven difficult to accurately associate specific neuronal projections, cell types, neurotransmitter systems and receptors with distinct phenotypes owing to its complexity. In this MiniReview, we present a recently invented technology known as Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). The DREADD technology is an emerging and transformative method that allows selective manipulation of G protein-coupled receptor (GPCR) signalling, and its broad-ranging usefulness in attention research is now beginning to emerge. We first describe the different DREADDs available and explain how unprecedented specificity of neuronal signalling can be achieved using DREADDs. We next discuss various studies performed in animal models of visual attention, where different brain regions and neuronal populations have been probed by DREADDs. We highlight the interplay between the dopamine (DA) and noradrenaline (NA) catecholamine systems in visual attention and explain why DREADD technology can untangle and help us better understand such complex systems in normal and malfunctioning conditions.
AB - Attention is a fundamental cognitive process involved in nearly all aspects of life. Abnormal attentional control is a symptom of many neurological disorders, most notably recognized in ADHD (attention deficit hyperactivity disorder). Although attentional performance and its malfunction has been a major area of investigation, it has proven difficult to accurately associate specific neuronal projections, cell types, neurotransmitter systems and receptors with distinct phenotypes owing to its complexity. In this MiniReview, we present a recently invented technology known as Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). The DREADD technology is an emerging and transformative method that allows selective manipulation of G protein-coupled receptor (GPCR) signalling, and its broad-ranging usefulness in attention research is now beginning to emerge. We first describe the different DREADDs available and explain how unprecedented specificity of neuronal signalling can be achieved using DREADDs. We next discuss various studies performed in animal models of visual attention, where different brain regions and neuronal populations have been probed by DREADDs. We highlight the interplay between the dopamine (DA) and noradrenaline (NA) catecholamine systems in visual attention and explain why DREADD technology can untangle and help us better understand such complex systems in normal and malfunctioning conditions.
KW - Journal Article
KW - Review
U2 - 10.1111/bcpt.12819
DO - 10.1111/bcpt.12819
M3 - Review
C2 - 28609587
VL - 121
SP - 373
EP - 381
JO - Basic and Clinical Pharmacology and Toxicology
JF - Basic and Clinical Pharmacology and Toxicology
SN - 1742-7835
IS - 5
ER -
ID: 186412135