Cerebral blood flow change in arterial hypoxemia is consistent with negligible oxygen tension in brain mitochondria

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Standard

Cerebral blood flow change in arterial hypoxemia is consistent with negligible oxygen tension in brain mitochondria. / Gjedde, Albert.

In: NeuroImage, Vol. 17, No. 4, 2002, p. 1876-81.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjedde, A 2002, 'Cerebral blood flow change in arterial hypoxemia is consistent with negligible oxygen tension in brain mitochondria', NeuroImage, vol. 17, no. 4, pp. 1876-81.

APA

Gjedde, A. (2002). Cerebral blood flow change in arterial hypoxemia is consistent with negligible oxygen tension in brain mitochondria. NeuroImage, 17(4), 1876-81.

Vancouver

Gjedde A. Cerebral blood flow change in arterial hypoxemia is consistent with negligible oxygen tension in brain mitochondria. NeuroImage. 2002;17(4):1876-81.

Author

Gjedde, Albert. / Cerebral blood flow change in arterial hypoxemia is consistent with negligible oxygen tension in brain mitochondria. In: NeuroImage. 2002 ; Vol. 17, No. 4. pp. 1876-81.

Bibtex

@article{16561940b31511debc73000ea68e967b,
title = "Cerebral blood flow change in arterial hypoxemia is consistent with negligible oxygen tension in brain mitochondria",
abstract = "The regulation of blood flow during neuronal activation is poorly understood. Current explanations of the mismatch between increased blood flow and oxygen consumption during neuronal excitation hold that blood flow must rise more than oxygen consumption to compensate for a low oxygen reserve in brain mitochondria. Contrary to the result of a previous study by Mintun et al. (2001), the present test of the hypothesis revealed no conflicts among the claims of unidirectional blood-brain transfer of oxygen, negligible oxygen in mitochondria, and measurements of cerebral blood flow and oxygen consumption. With a simple compartmental model of oxygen delivery to brain tissue, the test showed that neuronal excitation elicits identical increases of cerebral blood flow in normoxemia and hypoxemia, in complete agreement with the claim of a negligible reserve of oxygen in brain mitochondria in vivo.",
author = "Albert Gjedde",
year = "2002",
language = "English",
volume = "17",
pages = "1876--81",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Cerebral blood flow change in arterial hypoxemia is consistent with negligible oxygen tension in brain mitochondria

AU - Gjedde, Albert

PY - 2002

Y1 - 2002

N2 - The regulation of blood flow during neuronal activation is poorly understood. Current explanations of the mismatch between increased blood flow and oxygen consumption during neuronal excitation hold that blood flow must rise more than oxygen consumption to compensate for a low oxygen reserve in brain mitochondria. Contrary to the result of a previous study by Mintun et al. (2001), the present test of the hypothesis revealed no conflicts among the claims of unidirectional blood-brain transfer of oxygen, negligible oxygen in mitochondria, and measurements of cerebral blood flow and oxygen consumption. With a simple compartmental model of oxygen delivery to brain tissue, the test showed that neuronal excitation elicits identical increases of cerebral blood flow in normoxemia and hypoxemia, in complete agreement with the claim of a negligible reserve of oxygen in brain mitochondria in vivo.

AB - The regulation of blood flow during neuronal activation is poorly understood. Current explanations of the mismatch between increased blood flow and oxygen consumption during neuronal excitation hold that blood flow must rise more than oxygen consumption to compensate for a low oxygen reserve in brain mitochondria. Contrary to the result of a previous study by Mintun et al. (2001), the present test of the hypothesis revealed no conflicts among the claims of unidirectional blood-brain transfer of oxygen, negligible oxygen in mitochondria, and measurements of cerebral blood flow and oxygen consumption. With a simple compartmental model of oxygen delivery to brain tissue, the test showed that neuronal excitation elicits identical increases of cerebral blood flow in normoxemia and hypoxemia, in complete agreement with the claim of a negligible reserve of oxygen in brain mitochondria in vivo.

M3 - Journal article

C2 - 12498762

VL - 17

SP - 1876

EP - 1881

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 4

ER -

ID: 14944428