Candidate Interneurons Mediating the Resetting of the Locomotor Rhythm by Extensor Group I Afferents in the Cat
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Candidate Interneurons Mediating the Resetting of the Locomotor Rhythm by Extensor Group I Afferents in the Cat. / Domínguez-Rodríguez, L. E.; Stecina, K.; García-Ramírez, D. L.; Mena-Avila, E.; Milla-Cruz, J. J.; Martínez-Silva, L.; Zhang, M.; Hultborn, H.; Quevedo, J. N.
In: Neuroscience, Vol. 450, 2020, p. 96-112.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Candidate Interneurons Mediating the Resetting of the Locomotor Rhythm by Extensor Group I Afferents in the Cat
AU - Domínguez-Rodríguez, L. E.
AU - Stecina, K.
AU - García-Ramírez, D. L.
AU - Mena-Avila, E.
AU - Milla-Cruz, J. J.
AU - Martínez-Silva, L.
AU - Zhang, M.
AU - Hultborn, H.
AU - Quevedo, J. N.
PY - 2020
Y1 - 2020
N2 - Sensory information arising from limb movements controls the spinal locomotor circuitry to adapt the motor pattern to demands of the environment. Stimulation of extensor group (gr) I afferents during fictive locomotion in decerebrate cats prolongs the ongoing extension, and terminates ongoing flexion with an initiation of the subsequent extension, i. e. “resetting to extension”. Moreover, instead of the classical Ib non-reciprocal inhibition, stimulation of extensor gr I afferents produces a polysynaptic excitation in extensor motoneurons with latencies (∼3.5–4.0 ms) compatible with 3 interposed interneurons. We assume that some interneurons in this pathway actually belong to the rhythm-generating layer of the locomotor Central Pattern Generator (CPG), since their activity was correlated to a resetting of the rhythm. In the present work fictive locomotion was (mostly) induced by i.v. injection of nialamide followed by L-DOPA in paralyzed cats following decerebration and spinalization at C1 level. In some experiments, we extended previous observations during fictive locomotion on the emergence and locomotor state-dependence of polysynaptic excitatory postsynaptic potentials from extensor gr I afferents to ankle extensor motoneurons. However, the main focus was to record location and properties of interneurons (n = 62) that (i) were active during the extensor phase of fictive locomotion and (ii) received short-latency excitation (mono-, di- or polysynaptic) from extensor gr I afferents. We conclude that the interneurons recorded fulfill the characteristics to belong to the neuronal pathway activated by extensor gr I afferents during locomotion, and may contribute to the ‘resetting to extension’ as part of the locomotor CPG.
AB - Sensory information arising from limb movements controls the spinal locomotor circuitry to adapt the motor pattern to demands of the environment. Stimulation of extensor group (gr) I afferents during fictive locomotion in decerebrate cats prolongs the ongoing extension, and terminates ongoing flexion with an initiation of the subsequent extension, i. e. “resetting to extension”. Moreover, instead of the classical Ib non-reciprocal inhibition, stimulation of extensor gr I afferents produces a polysynaptic excitation in extensor motoneurons with latencies (∼3.5–4.0 ms) compatible with 3 interposed interneurons. We assume that some interneurons in this pathway actually belong to the rhythm-generating layer of the locomotor Central Pattern Generator (CPG), since their activity was correlated to a resetting of the rhythm. In the present work fictive locomotion was (mostly) induced by i.v. injection of nialamide followed by L-DOPA in paralyzed cats following decerebration and spinalization at C1 level. In some experiments, we extended previous observations during fictive locomotion on the emergence and locomotor state-dependence of polysynaptic excitatory postsynaptic potentials from extensor gr I afferents to ankle extensor motoneurons. However, the main focus was to record location and properties of interneurons (n = 62) that (i) were active during the extensor phase of fictive locomotion and (ii) received short-latency excitation (mono-, di- or polysynaptic) from extensor gr I afferents. We conclude that the interneurons recorded fulfill the characteristics to belong to the neuronal pathway activated by extensor gr I afferents during locomotion, and may contribute to the ‘resetting to extension’ as part of the locomotor CPG.
KW - afferent
KW - interneuron
KW - locomotion
KW - sensory-motor system
KW - spinal cord
U2 - 10.1016/j.neuroscience.2020.09.017
DO - 10.1016/j.neuroscience.2020.09.017
M3 - Journal article
C2 - 32946952
AN - SCOPUS:85092108941
VL - 450
SP - 96
EP - 112
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
ER -
ID: 254516129