Ca2+-activated nonselective cationic current (I(CAN)) in turtle motoneurons

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Ca2+-activated nonselective cationic current (I(CAN)) in turtle motoneurons. / Perrier, Jean François; Hounsgaard, Jørn.

In: Journal of Neurophysiology, Vol. 82, No. 2, 01.01.1999, p. 730-735.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Perrier, JF & Hounsgaard, J 1999, 'Ca2+-activated nonselective cationic current (I(CAN)) in turtle motoneurons', Journal of Neurophysiology, vol. 82, no. 2, pp. 730-735. https://doi.org/10.1152/jn.1999.82.2.730

APA

Perrier, J. F., & Hounsgaard, J. (1999). Ca2+-activated nonselective cationic current (I(CAN)) in turtle motoneurons. Journal of Neurophysiology, 82(2), 730-735. https://doi.org/10.1152/jn.1999.82.2.730

Vancouver

Perrier JF, Hounsgaard J. Ca2+-activated nonselective cationic current (I(CAN)) in turtle motoneurons. Journal of Neurophysiology. 1999 Jan 1;82(2):730-735. https://doi.org/10.1152/jn.1999.82.2.730

Author

Perrier, Jean François ; Hounsgaard, Jørn. / Ca2+-activated nonselective cationic current (I(CAN)) in turtle motoneurons. In: Journal of Neurophysiology. 1999 ; Vol. 82, No. 2. pp. 730-735.

Bibtex

@article{b875e35dca634b48ba7c432818c6fdf0,
title = "Ca2+-activated nonselective cationic current (I(CAN)) in turtle motoneurons",
abstract = "The presence of a calcium-activated nonspecific cationic (CAN) current in turtle motoneurons and its involvement in plateau potentials, bistability, and windup was investigated by intracellular recordings in a spinal cord slice preparation. In the presence of tetraethylammonium (TEA) and tetrodotoxin (TTX), calcium action potentials evoked by depolarizing current pulses were always followed by an afterdepolarization associated with a decrease in input resistance. The presence of the afterdepolarization depended on the calcium spike and not on membrane potential. Replacement of extracellular sodium by choline or N-methyl-D-glucamine (NMDG) reduced the afterdepolarization, confirming that it was mediated by a CAN current. Plateau potentials and windup were evoked in response to intracellular current pulses in the presence of agonist for different metabotropic receptors. Replacement of extracellular sodium by choline or NMDG did not abolish the generation of plateau potentials, bistability, or windup, showing that Na+ was not the principal charge carrier. It is concluded that plateau potentials, bistability and windup in turtle motoneurons do not depend on a CAN current even though its presence can be detected.",
author = "Perrier, {Jean Fran{\c c}ois} and J{\o}rn Hounsgaard",
year = "1999",
month = jan,
day = "1",
doi = "10.1152/jn.1999.82.2.730",
language = "English",
volume = "82",
pages = "730--735",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - Ca2+-activated nonselective cationic current (I(CAN)) in turtle motoneurons

AU - Perrier, Jean François

AU - Hounsgaard, Jørn

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The presence of a calcium-activated nonspecific cationic (CAN) current in turtle motoneurons and its involvement in plateau potentials, bistability, and windup was investigated by intracellular recordings in a spinal cord slice preparation. In the presence of tetraethylammonium (TEA) and tetrodotoxin (TTX), calcium action potentials evoked by depolarizing current pulses were always followed by an afterdepolarization associated with a decrease in input resistance. The presence of the afterdepolarization depended on the calcium spike and not on membrane potential. Replacement of extracellular sodium by choline or N-methyl-D-glucamine (NMDG) reduced the afterdepolarization, confirming that it was mediated by a CAN current. Plateau potentials and windup were evoked in response to intracellular current pulses in the presence of agonist for different metabotropic receptors. Replacement of extracellular sodium by choline or NMDG did not abolish the generation of plateau potentials, bistability, or windup, showing that Na+ was not the principal charge carrier. It is concluded that plateau potentials, bistability and windup in turtle motoneurons do not depend on a CAN current even though its presence can be detected.

AB - The presence of a calcium-activated nonspecific cationic (CAN) current in turtle motoneurons and its involvement in plateau potentials, bistability, and windup was investigated by intracellular recordings in a spinal cord slice preparation. In the presence of tetraethylammonium (TEA) and tetrodotoxin (TTX), calcium action potentials evoked by depolarizing current pulses were always followed by an afterdepolarization associated with a decrease in input resistance. The presence of the afterdepolarization depended on the calcium spike and not on membrane potential. Replacement of extracellular sodium by choline or N-methyl-D-glucamine (NMDG) reduced the afterdepolarization, confirming that it was mediated by a CAN current. Plateau potentials and windup were evoked in response to intracellular current pulses in the presence of agonist for different metabotropic receptors. Replacement of extracellular sodium by choline or NMDG did not abolish the generation of plateau potentials, bistability, or windup, showing that Na+ was not the principal charge carrier. It is concluded that plateau potentials, bistability and windup in turtle motoneurons do not depend on a CAN current even though its presence can be detected.

UR - http://www.scopus.com/inward/record.url?scp=0032765652&partnerID=8YFLogxK

U2 - 10.1152/jn.1999.82.2.730

DO - 10.1152/jn.1999.82.2.730

M3 - Journal article

C2 - 10444670

AN - SCOPUS:0032765652

VL - 82

SP - 730

EP - 735

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 2

ER -

ID: 237699236