Ca++ dependent bistability induced by serotonin in spinal motoneurons

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Ca++ dependent bistability induced by serotonin in spinal motoneurons. / Hounsgaard, J.; Kiehn, O.

In: Experimental Brain Research, Vol. 57, No. 2, 01.01.1985, p. 422-425.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hounsgaard, J & Kiehn, O 1985, 'Ca++ dependent bistability induced by serotonin in spinal motoneurons', Experimental Brain Research, vol. 57, no. 2, pp. 422-425. https://doi.org/10.1007/BF00236551

APA

Hounsgaard, J., & Kiehn, O. (1985). Ca++ dependent bistability induced by serotonin in spinal motoneurons. Experimental Brain Research, 57(2), 422-425. https://doi.org/10.1007/BF00236551

Vancouver

Hounsgaard J, Kiehn O. Ca++ dependent bistability induced by serotonin in spinal motoneurons. Experimental Brain Research. 1985 Jan 1;57(2):422-425. https://doi.org/10.1007/BF00236551

Author

Hounsgaard, J. ; Kiehn, O. / Ca++ dependent bistability induced by serotonin in spinal motoneurons. In: Experimental Brain Research. 1985 ; Vol. 57, No. 2. pp. 422-425.

Bibtex

@article{4dfe355113d940be870ce686f109c1cc,
title = "Ca++ dependent bistability induced by serotonin in spinal motoneurons",
abstract = "The plateau potential, responsible for the bistable state of spinal motoneurons, recently described in the decerebrate cat, was suggested to depend on serotonin (Hounsgaard et al. 1984). In an in vitro preparation of the spinal cord of the turtle we now show that serotonin, applied directly to the bath, transforms the intrinsic response properties of motoneurons, uncovering a plateau potential and voltage sensitive bistability. The changes induced by serotonin were blocked by Mn++, while the plateau potential and the bistability remained after application of tetrodotoxin. We conclude that serotonin controls the expression of a Ca++ dependent plateau potential in motoneurons.",
keywords = "Bistable state, Motoneurons, Serotonin, Spinal cord",
author = "J. Hounsgaard and O. Kiehn",
year = "1985",
month = jan,
day = "1",
doi = "10.1007/BF00236551",
language = "English",
volume = "57",
pages = "422--425",
journal = "Experimental Brain Research",
issn = "0014-4819",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Ca++ dependent bistability induced by serotonin in spinal motoneurons

AU - Hounsgaard, J.

AU - Kiehn, O.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - The plateau potential, responsible for the bistable state of spinal motoneurons, recently described in the decerebrate cat, was suggested to depend on serotonin (Hounsgaard et al. 1984). In an in vitro preparation of the spinal cord of the turtle we now show that serotonin, applied directly to the bath, transforms the intrinsic response properties of motoneurons, uncovering a plateau potential and voltage sensitive bistability. The changes induced by serotonin were blocked by Mn++, while the plateau potential and the bistability remained after application of tetrodotoxin. We conclude that serotonin controls the expression of a Ca++ dependent plateau potential in motoneurons.

AB - The plateau potential, responsible for the bistable state of spinal motoneurons, recently described in the decerebrate cat, was suggested to depend on serotonin (Hounsgaard et al. 1984). In an in vitro preparation of the spinal cord of the turtle we now show that serotonin, applied directly to the bath, transforms the intrinsic response properties of motoneurons, uncovering a plateau potential and voltage sensitive bistability. The changes induced by serotonin were blocked by Mn++, while the plateau potential and the bistability remained after application of tetrodotoxin. We conclude that serotonin controls the expression of a Ca++ dependent plateau potential in motoneurons.

KW - Bistable state

KW - Motoneurons

KW - Serotonin

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=0021984367&partnerID=8YFLogxK

U2 - 10.1007/BF00236551

DO - 10.1007/BF00236551

M3 - Journal article

C2 - 2578974

AN - SCOPUS:0021984367

VL - 57

SP - 422

EP - 425

JO - Experimental Brain Research

JF - Experimental Brain Research

SN - 0014-4819

IS - 2

ER -

ID: 194981132