Burst-suppression is reactive to photic stimulation in comatose children with acquired brain injury
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Burst-suppression is reactive to photic stimulation in comatose children with acquired brain injury. / Nita, Dragos A.; Moldovan, Mihai; Sharma, Roy; Avramescu, Sinziana; Otsubo, Hiroshi; Hahn, Cecil D.
In: Clinical Neurophysiology, Vol. 127, No. 8, 08.2016, p. 2921-2930.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Burst-suppression is reactive to photic stimulation in comatose children with acquired brain injury
AU - Nita, Dragos A.
AU - Moldovan, Mihai
AU - Sharma, Roy
AU - Avramescu, Sinziana
AU - Otsubo, Hiroshi
AU - Hahn, Cecil D.
PY - 2016/8
Y1 - 2016/8
N2 - Objective: Burst-suppression is an electroencephalographic pattern observed during coma. In individuals without known brain pathologies undergoing deep general anesthesia, somatosensory stimulation transiently increases the occurrence of bursts. We investigated the reactivity of burst-suppression in children with acquired brain injury.Methods: Intensive care unit electroencephalographic monitoring recordings containing burst-suppression were obtained from 5 comatose children with acquired brain injury of various etiologies. Intermittent photic stimulation was performed at 1 Hz for 1 min to assess reactivity. We quantified reactivity by measuring the change in the burst ratio (fraction of time in burst) following photic stimulation.Results: Photic stimulation evoked bursts in all patients, resulting in a transient increase in the burst ratio, while the mean heart rate remained unchanged. The regression slope of the change in burst ratio, referred to as the standardized burst ratio reactivity, correlated with subjects' Glasgow Coma Scale scores.Conclusions: Reactivity of the burst-suppression pattern to photic stimulation occurs across diverse coma etiologies. Standardized burst ratio reactivity appears to reflect coma severity.
AB - Objective: Burst-suppression is an electroencephalographic pattern observed during coma. In individuals without known brain pathologies undergoing deep general anesthesia, somatosensory stimulation transiently increases the occurrence of bursts. We investigated the reactivity of burst-suppression in children with acquired brain injury.Methods: Intensive care unit electroencephalographic monitoring recordings containing burst-suppression were obtained from 5 comatose children with acquired brain injury of various etiologies. Intermittent photic stimulation was performed at 1 Hz for 1 min to assess reactivity. We quantified reactivity by measuring the change in the burst ratio (fraction of time in burst) following photic stimulation.Results: Photic stimulation evoked bursts in all patients, resulting in a transient increase in the burst ratio, while the mean heart rate remained unchanged. The regression slope of the change in burst ratio, referred to as the standardized burst ratio reactivity, correlated with subjects' Glasgow Coma Scale scores.Conclusions: Reactivity of the burst-suppression pattern to photic stimulation occurs across diverse coma etiologies. Standardized burst ratio reactivity appears to reflect coma severity.
KW - Coma
KW - EEG
KW - Children
KW - Burst-suppression
KW - Reactivity
U2 - 10.1016/j.clinph.2016.03.029
DO - 10.1016/j.clinph.2016.03.029
M3 - Journal article
C2 - 27266662
VL - 127
SP - 2921
EP - 2930
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 8
ER -
ID: 165977376