Brain barriers and their potential role in migraine pathophysiology

Research output: Contribution to journal › Review › Research › peer-review

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Brain barriers and their potential role in migraine pathophysiology. / Wiggers, Astrid; Ashina, Håkan; Hadjikhani, Nouchine; Sagare, Abhay; Zlokovic, Berislav V.; Lauritzen, Martin; Ashina, Messoud.

In: Journal of Headache and Pain, Vol. 23, No. 1, 16, 12.2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Wiggers, A, Ashina, H, Hadjikhani, N, Sagare, A, Zlokovic, BV, Lauritzen, M & Ashina, M 2022, 'Brain barriers and their potential role in migraine pathophysiology', Journal of Headache and Pain, vol. 23, no. 1, 16. https://doi.org/10.1186/s10194-021-01365-w

APA

Wiggers, A., Ashina, H., Hadjikhani, N., Sagare, A., Zlokovic, B. V., Lauritzen, M., & Ashina, M. (2022). Brain barriers and their potential role in migraine pathophysiology. Journal of Headache and Pain, 23(1), [16]. https://doi.org/10.1186/s10194-021-01365-w

Vancouver

Wiggers A, Ashina H, Hadjikhani N, Sagare A, Zlokovic BV, Lauritzen M et al. Brain barriers and their potential role in migraine pathophysiology. Journal of Headache and Pain. 2022 Dec;23(1). 16. https://doi.org/10.1186/s10194-021-01365-w

Author

Wiggers, Astrid ; Ashina, Håkan ; Hadjikhani, Nouchine ; Sagare, Abhay ; Zlokovic, Berislav V. ; Lauritzen, Martin ; Ashina, Messoud. / Brain barriers and their potential role in migraine pathophysiology. In: Journal of Headache and Pain. 2022 ; Vol. 23, No. 1.

Bibtex

@article{7d896824a65a4103b196946e7254398c,

title = "Brain barriers and their potential role in migraine pathophysiology",

abstract = "Migraine is a ubiquitous neurologic disease that afflicts people of all ages. Its molecular pathogenesis involves peptides that promote intracranial vasodilation and modulate nociceptive transmission upon release from sensory afferents of cells in the trigeminal ganglion and parasympathetic efferents of cells in the sphenopalatine ganglion. Experimental data have confirmed that intravenous infusion of these vasoactive peptides induce migraine attacks in people with migraine, but it remains a point of scientific contention whether their site of action lies outside or within the central nervous system. In this context, it has been hypothesized that transient dysfunction of brain barriers before or during migraine attacks might facilitate the passage of migraine-inducing peptides into the central nervous system. Here, we review evidence suggestive of brain barrier dysfunction in migraine pathogenesis and conclude with lessons learned in order to provide directions for future research efforts.",

keywords = "Aura, Blood-brain barrier, Headache, Trigeminovascular system",

author = "Astrid Wiggers and H{\aa}kan Ashina and Nouchine Hadjikhani and Abhay Sagare and Zlokovic, {Berislav V.} and Martin Lauritzen and Messoud Ashina",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s10194-021-01365-w",

language = "English",

volume = "23",

journal = "Journal of Headache and Pain",

issn = "1129-2369",

publisher = "Springer",

number = "1",

}

RIS

TY - JOUR

T1 - Brain barriers and their potential role in migraine pathophysiology

AU - Wiggers, Astrid

AU - Ashina, Håkan

AU - Hadjikhani, Nouchine

AU - Sagare, Abhay

AU - Zlokovic, Berislav V.

AU - Lauritzen, Martin

AU - Ashina, Messoud

PY - 2022/12

Y1 - 2022/12

N2 - Migraine is a ubiquitous neurologic disease that afflicts people of all ages. Its molecular pathogenesis involves peptides that promote intracranial vasodilation and modulate nociceptive transmission upon release from sensory afferents of cells in the trigeminal ganglion and parasympathetic efferents of cells in the sphenopalatine ganglion. Experimental data have confirmed that intravenous infusion of these vasoactive peptides induce migraine attacks in people with migraine, but it remains a point of scientific contention whether their site of action lies outside or within the central nervous system. In this context, it has been hypothesized that transient dysfunction of brain barriers before or during migraine attacks might facilitate the passage of migraine-inducing peptides into the central nervous system. Here, we review evidence suggestive of brain barrier dysfunction in migraine pathogenesis and conclude with lessons learned in order to provide directions for future research efforts.

AB - Migraine is a ubiquitous neurologic disease that afflicts people of all ages. Its molecular pathogenesis involves peptides that promote intracranial vasodilation and modulate nociceptive transmission upon release from sensory afferents of cells in the trigeminal ganglion and parasympathetic efferents of cells in the sphenopalatine ganglion. Experimental data have confirmed that intravenous infusion of these vasoactive peptides induce migraine attacks in people with migraine, but it remains a point of scientific contention whether their site of action lies outside or within the central nervous system. In this context, it has been hypothesized that transient dysfunction of brain barriers before or during migraine attacks might facilitate the passage of migraine-inducing peptides into the central nervous system. Here, we review evidence suggestive of brain barrier dysfunction in migraine pathogenesis and conclude with lessons learned in order to provide directions for future research efforts.

KW - Aura

KW - Blood-brain barrier

KW - Headache

KW - Trigeminovascular system

U2 - 10.1186/s10194-021-01365-w

DO - 10.1186/s10194-021-01365-w

M3 - Review

C2 - 35081902

AN - SCOPUS:85123610847

VL - 23

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

SN - 1129-2369

IS - 1

M1 - 16

ER -

ID: 291362327

Department of Neuroscience