Blood-brain glucose transport in the conscious rat: comparison of the intravenous and intracarotid injection methods
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Blood-brain glucose transport in the conscious rat: comparison of the intravenous and intracarotid injection methods. / Gjedde, Albert; Rasmussen, Mette.
In: Journal of Neurochemistry, Vol. 35, No. 6, 1980, p. 1375-81.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Blood-brain glucose transport in the conscious rat: comparison of the intravenous and intracarotid injection methods
AU - Gjedde, Albert
AU - Rasmussen, Mette
PY - 1980
Y1 - 1980
N2 - The unidirectioal transfer of D-glucose from blood to parietal cortex tissue of the brain of awake rats was measured by single intravenous injection of tracer glucose, as well as by single intracarotid injection according to the method of Oldendorf. The maximal unidirectional blood-brain glucose transfer rate (Tmax) was 407 mumol (100 g)-1 min-1 when measured by intravenous injection, and 352 mumol (100 g)-1 min-1 when measured by intracarotid injection. The half-saturation constants (Km) were 7.8 mM and 16.8 mM, respectively. The comparison shows that the two methods give similar results when cerebral perfusion is assessed accurately.
AB - The unidirectioal transfer of D-glucose from blood to parietal cortex tissue of the brain of awake rats was measured by single intravenous injection of tracer glucose, as well as by single intracarotid injection according to the method of Oldendorf. The maximal unidirectional blood-brain glucose transfer rate (Tmax) was 407 mumol (100 g)-1 min-1 when measured by intravenous injection, and 352 mumol (100 g)-1 min-1 when measured by intracarotid injection. The half-saturation constants (Km) were 7.8 mM and 16.8 mM, respectively. The comparison shows that the two methods give similar results when cerebral perfusion is assessed accurately.
M3 - Journal article
C2 - 7441255
VL - 35
SP - 1375
EP - 1381
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 6
ER -
ID: 14943119