Blood-brain glucose transfer: repression in chronic hyperglycemia

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Blood-brain glucose transfer: repression in chronic hyperglycemia. / Gjedde, Albert; Crone, Christian.

In: Science, Vol. 214, No. 4519, 1981, p. 456-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjedde, A & Crone, C 1981, 'Blood-brain glucose transfer: repression in chronic hyperglycemia', Science, vol. 214, no. 4519, pp. 456-7.

APA

Gjedde, A., & Crone, C. (1981). Blood-brain glucose transfer: repression in chronic hyperglycemia. Science, 214(4519), 456-7.

Vancouver

Gjedde A, Crone C. Blood-brain glucose transfer: repression in chronic hyperglycemia. Science. 1981;214(4519):456-7.

Author

Gjedde, Albert ; Crone, Christian. / Blood-brain glucose transfer: repression in chronic hyperglycemia. In: Science. 1981 ; Vol. 214, No. 4519. pp. 456-7.

Bibtex

@article{0688fe60b31511debc73000ea68e967b,
title = "Blood-brain glucose transfer: repression in chronic hyperglycemia",
abstract = "Diabetic patients with increased plasma glucose concentrations may develop cerebral symptoms of hypoglycemia when their plasma glucose is rapidly lowered to normal concentrations. The symptoms may indicate insufficient transport of glucose from blood to brain. In rats with chronic hyperglycemia the maximum glucose transport capacity of the blood-brain barrier decreased from 400 to 290 micromoles per 100 grams per minute. When plasma glucose was lowered to normal values, the glucose transport rate into brain was 20 percent below normal. This suggests that repressive changes of the glucose transport mechanism occur in brain endothelial cells in response to increased plasma glucose.",
author = "Albert Gjedde and Christian Crone",
year = "1981",
language = "English",
volume = "214",
pages = "456--7",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4519",

}

RIS

TY - JOUR

T1 - Blood-brain glucose transfer: repression in chronic hyperglycemia

AU - Gjedde, Albert

AU - Crone, Christian

PY - 1981

Y1 - 1981

N2 - Diabetic patients with increased plasma glucose concentrations may develop cerebral symptoms of hypoglycemia when their plasma glucose is rapidly lowered to normal concentrations. The symptoms may indicate insufficient transport of glucose from blood to brain. In rats with chronic hyperglycemia the maximum glucose transport capacity of the blood-brain barrier decreased from 400 to 290 micromoles per 100 grams per minute. When plasma glucose was lowered to normal values, the glucose transport rate into brain was 20 percent below normal. This suggests that repressive changes of the glucose transport mechanism occur in brain endothelial cells in response to increased plasma glucose.

AB - Diabetic patients with increased plasma glucose concentrations may develop cerebral symptoms of hypoglycemia when their plasma glucose is rapidly lowered to normal concentrations. The symptoms may indicate insufficient transport of glucose from blood to brain. In rats with chronic hyperglycemia the maximum glucose transport capacity of the blood-brain barrier decreased from 400 to 290 micromoles per 100 grams per minute. When plasma glucose was lowered to normal values, the glucose transport rate into brain was 20 percent below normal. This suggests that repressive changes of the glucose transport mechanism occur in brain endothelial cells in response to increased plasma glucose.

M3 - Journal article

C2 - 7027439

VL - 214

SP - 456

EP - 457

JO - Science

JF - Science

SN - 0036-8075

IS - 4519

ER -

ID: 14943543