Bidirectional electrical coupling between inspiratory motoneurons in the newborn mouse nucleus ambiguus

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bidirectional electrical coupling between inspiratory motoneurons in the newborn mouse nucleus ambiguus. / Rekling, J C; Feldman, J L.

In: Journal of Neurophysiology, Vol. 78, No. 6, 1997, p. 3508-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rekling, JC & Feldman, JL 1997, 'Bidirectional electrical coupling between inspiratory motoneurons in the newborn mouse nucleus ambiguus', Journal of Neurophysiology, vol. 78, no. 6, pp. 3508-10.

APA

Rekling, J. C., & Feldman, J. L. (1997). Bidirectional electrical coupling between inspiratory motoneurons in the newborn mouse nucleus ambiguus. Journal of Neurophysiology, 78(6), 3508-10.

Vancouver

Rekling JC, Feldman JL. Bidirectional electrical coupling between inspiratory motoneurons in the newborn mouse nucleus ambiguus. Journal of Neurophysiology. 1997;78(6):3508-10.

Author

Rekling, J C ; Feldman, J L. / Bidirectional electrical coupling between inspiratory motoneurons in the newborn mouse nucleus ambiguus. In: Journal of Neurophysiology. 1997 ; Vol. 78, No. 6. pp. 3508-10.

Bibtex

@article{76baf1a0cde911dd9473000ea68e967b,
title = "Bidirectional electrical coupling between inspiratory motoneurons in the newborn mouse nucleus ambiguus",
abstract = "Some spinal and brain stem motoneurons are electrically coupled in the early postnatal period. To test whether respiratory motoneurons in the brain stem are electrically coupled, we performed single and dual whole cell patch recordings from presumptive motoneurons in the nucleus ambiguus in a rhythmically active brain stem slice from newborn mice. Two of eight (25%) biocytin-injected neurons showed dye-coupling and 4 of 11 (36%) of intracellularly recorded pairs of neurons showed evidence of bidirectional electrical coupling. Impulse activity in one cell elicited small spikelets in the other and hyperpolarization of one cell led to hyperpolarization of the other with a coupling ratio (DeltaV2:DeltaV1) of 0.03-0.14. We conclude that inspiratory ambiguus motoneurons in the newborn mouse brain stem are bidirectionally electrically coupled, which may serve to transmit or coordinate signals, chemical or electrical.",
author = "Rekling, {J C} and Feldman, {J L}",
note = "Keywords: Animals; Animals, Newborn; Brain Stem; Excitatory Postsynaptic Potentials; Gap Junctions; Membrane Potentials; Mice; Mice, Inbred BALB C; Motor Neurons; Patch-Clamp Techniques; Pharynx; Respiration",
year = "1997",
language = "English",
volume = "78",
pages = "3508--10",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "6",

}

RIS

TY - JOUR

T1 - Bidirectional electrical coupling between inspiratory motoneurons in the newborn mouse nucleus ambiguus

AU - Rekling, J C

AU - Feldman, J L

N1 - Keywords: Animals; Animals, Newborn; Brain Stem; Excitatory Postsynaptic Potentials; Gap Junctions; Membrane Potentials; Mice; Mice, Inbred BALB C; Motor Neurons; Patch-Clamp Techniques; Pharynx; Respiration

PY - 1997

Y1 - 1997

N2 - Some spinal and brain stem motoneurons are electrically coupled in the early postnatal period. To test whether respiratory motoneurons in the brain stem are electrically coupled, we performed single and dual whole cell patch recordings from presumptive motoneurons in the nucleus ambiguus in a rhythmically active brain stem slice from newborn mice. Two of eight (25%) biocytin-injected neurons showed dye-coupling and 4 of 11 (36%) of intracellularly recorded pairs of neurons showed evidence of bidirectional electrical coupling. Impulse activity in one cell elicited small spikelets in the other and hyperpolarization of one cell led to hyperpolarization of the other with a coupling ratio (DeltaV2:DeltaV1) of 0.03-0.14. We conclude that inspiratory ambiguus motoneurons in the newborn mouse brain stem are bidirectionally electrically coupled, which may serve to transmit or coordinate signals, chemical or electrical.

AB - Some spinal and brain stem motoneurons are electrically coupled in the early postnatal period. To test whether respiratory motoneurons in the brain stem are electrically coupled, we performed single and dual whole cell patch recordings from presumptive motoneurons in the nucleus ambiguus in a rhythmically active brain stem slice from newborn mice. Two of eight (25%) biocytin-injected neurons showed dye-coupling and 4 of 11 (36%) of intracellularly recorded pairs of neurons showed evidence of bidirectional electrical coupling. Impulse activity in one cell elicited small spikelets in the other and hyperpolarization of one cell led to hyperpolarization of the other with a coupling ratio (DeltaV2:DeltaV1) of 0.03-0.14. We conclude that inspiratory ambiguus motoneurons in the newborn mouse brain stem are bidirectionally electrically coupled, which may serve to transmit or coordinate signals, chemical or electrical.

M3 - Journal article

C2 - 9405571

VL - 78

SP - 3508

EP - 3510

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 6

ER -

ID: 9255930