Bi-affinity alpha 1-adrenoceptor binding in normal rat brain in vivo.

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Standard

Bi-affinity alpha 1-adrenoceptor binding in normal rat brain in vivo. / Gjedde, A; Dyve, S; Yang, Y J; McHugh, M; Pappius, H M.

In: Synapse, Vol. 9, No. 1, 1991, p. 1-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjedde, A, Dyve, S, Yang, YJ, McHugh, M & Pappius, HM 1991, 'Bi-affinity alpha 1-adrenoceptor binding in normal rat brain in vivo.', Synapse, vol. 9, no. 1, pp. 1-6. https://doi.org/10.1002/syn.890090102

APA

Gjedde, A., Dyve, S., Yang, Y. J., McHugh, M., & Pappius, H. M. (1991). Bi-affinity alpha 1-adrenoceptor binding in normal rat brain in vivo. Synapse, 9(1), 1-6. https://doi.org/10.1002/syn.890090102

Vancouver

Gjedde A, Dyve S, Yang YJ, McHugh M, Pappius HM. Bi-affinity alpha 1-adrenoceptor binding in normal rat brain in vivo. Synapse. 1991;9(1):1-6. https://doi.org/10.1002/syn.890090102

Author

Gjedde, A ; Dyve, S ; Yang, Y J ; McHugh, M ; Pappius, H M. / Bi-affinity alpha 1-adrenoceptor binding in normal rat brain in vivo. In: Synapse. 1991 ; Vol. 9, No. 1. pp. 1-6.

Bibtex

@article{358669a0b31511debc73000ea68e967b,
title = "Bi-affinity alpha 1-adrenoceptor binding in normal rat brain in vivo.",
abstract = "The specific binding in rat brain in vivo of [125I]HEAT ([125I]iodo-2-[beta-(4-hydroxyphenyl)ethylamino methyl), a selective alpha 1-adrenoceptor ligand, was analyzed by a method designed to distinguish sites with different affinities. The data indicate at least two sites with different affinities for the alpha 1-adrenoreceptor in normal rat brain in vivo: a high-affinity site with Kd (half-saturation constant) of 3.6 +/- 0.7 nM (AV +/- SD), and a low-affinity site with Kd of 668 +/- 552 nM. The density (Bmax) of the high-affinity site in nine brain regions--auditory, visual, sensorimotor (four layers) and frontal cortex and lateral thalamic and medial geniculate nuclei--varied from 2.2 +/- 0.8 to 14.6 +/- 0.6 pmole/g, while the low-affinity range was 149 +/- 44 to 577 +/- 30 pmole/g. The results also revealed a very dynamic relationship between the two sites regulated by the concentration of the ligand ranging from 80% preponderance of the high-affinity sites at low ligand concentrations to more than 95% preponderance of the low-affinity sites at high ligand concentrations.",
author = "A Gjedde and S Dyve and Yang, {Y J} and M McHugh and Pappius, {H M}",
year = "1991",
doi = "10.1002/syn.890090102",
language = "English",
volume = "9",
pages = "1--6",
journal = "Synapse",
issn = "0887-4476",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Bi-affinity alpha 1-adrenoceptor binding in normal rat brain in vivo.

AU - Gjedde, A

AU - Dyve, S

AU - Yang, Y J

AU - McHugh, M

AU - Pappius, H M

PY - 1991

Y1 - 1991

N2 - The specific binding in rat brain in vivo of [125I]HEAT ([125I]iodo-2-[beta-(4-hydroxyphenyl)ethylamino methyl), a selective alpha 1-adrenoceptor ligand, was analyzed by a method designed to distinguish sites with different affinities. The data indicate at least two sites with different affinities for the alpha 1-adrenoreceptor in normal rat brain in vivo: a high-affinity site with Kd (half-saturation constant) of 3.6 +/- 0.7 nM (AV +/- SD), and a low-affinity site with Kd of 668 +/- 552 nM. The density (Bmax) of the high-affinity site in nine brain regions--auditory, visual, sensorimotor (four layers) and frontal cortex and lateral thalamic and medial geniculate nuclei--varied from 2.2 +/- 0.8 to 14.6 +/- 0.6 pmole/g, while the low-affinity range was 149 +/- 44 to 577 +/- 30 pmole/g. The results also revealed a very dynamic relationship between the two sites regulated by the concentration of the ligand ranging from 80% preponderance of the high-affinity sites at low ligand concentrations to more than 95% preponderance of the low-affinity sites at high ligand concentrations.

AB - The specific binding in rat brain in vivo of [125I]HEAT ([125I]iodo-2-[beta-(4-hydroxyphenyl)ethylamino methyl), a selective alpha 1-adrenoceptor ligand, was analyzed by a method designed to distinguish sites with different affinities. The data indicate at least two sites with different affinities for the alpha 1-adrenoreceptor in normal rat brain in vivo: a high-affinity site with Kd (half-saturation constant) of 3.6 +/- 0.7 nM (AV +/- SD), and a low-affinity site with Kd of 668 +/- 552 nM. The density (Bmax) of the high-affinity site in nine brain regions--auditory, visual, sensorimotor (four layers) and frontal cortex and lateral thalamic and medial geniculate nuclei--varied from 2.2 +/- 0.8 to 14.6 +/- 0.6 pmole/g, while the low-affinity range was 149 +/- 44 to 577 +/- 30 pmole/g. The results also revealed a very dynamic relationship between the two sites regulated by the concentration of the ligand ranging from 80% preponderance of the high-affinity sites at low ligand concentrations to more than 95% preponderance of the low-affinity sites at high ligand concentrations.

U2 - 10.1002/syn.890090102

DO - 10.1002/syn.890090102

M3 - Journal article

C2 - 1665592

VL - 9

SP - 1

EP - 6

JO - Synapse

JF - Synapse

SN - 0887-4476

IS - 1

ER -

ID: 14946095