Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs

Research output: Contribution to journalJournal articleResearchpeer-review

  • Nanna Marie Lind
  • Gjedde, Albert
  • Anette Moustgaard
  • Aage K. Olsen
  • Svend Borup Jensen
  • Steen Jakobsen
  • Sidse Marie Arnfred
  • Axel Kornerup Hansen
  • Ralf Peter Hemmingsen
  • Paul Cumming
Behavioral response to novelty in rats has been linked both to dopamine transmission in the ventral striatum, and to propensity to self-administer psychostimulant drugs. In order to probe the relationship between behavioral response to novelty and dopamine systems we have developed a behavioral model for correlation with positron emission tomography (PET) of dopamine transmission in brain of Göttingen minipigs. In the present study, we measured exploration of a novel object by recording the number of contacts, and duration of contact with a novel object, in groups of six male and six female adult minipigs. We hypothesized that these novelty scores would correlate with the amphetamine-evoked dopamine release in ventral striatum, measured 2 weeks later in a PET study of the availability of binding sites for the dopamine D2/3 antagonist [11C]raclopride. There were significant correlations between duration of contact with a novel object and the amphetamine-evoked reductions in binding potential (DeltapB) in the left ventral striatum of the 12 animals; Comparison of results by gender revealed that the correlation was driven mainly by the male group, and was not present in the female group. We interpret these results to show that propensity to explore an unfamiliar object is relatively elevated in pigs with low basal occupancy of dopamine D2/3 receptors by endogenous dopamine, and with high amphetamine-induced occupancy of released dopamine in the male pigs.
Original languageEnglish
JournalBehavioural Brain Research
Issue number2
Pages (from-to)172-7
Number of pages5
Publication statusPublished - 2005
Externally publishedYes

ID: 14944331