Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice

Research output: Contribution to journal › Journal article › Research › peer-review

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Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice. / Cregg, Jared M.; Sidhu, Simrandeep K.; Leiras, Roberto; Kiehn, Ole.

In: Nature Neuroscience, Vol. 27, 2024, p. 716–727.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cregg, JM, Sidhu, SK, Leiras, R & Kiehn, O 2024, 'Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice', Nature Neuroscience, vol. 27, pp. 716–727. https://doi.org/10.1038/s41593-024-01569-8

APA

Cregg, J. M., Sidhu, S. K., Leiras, R., & Kiehn, O. (2024). Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice. Nature Neuroscience, 27, 716–727. https://doi.org/10.1038/s41593-024-01569-8

Vancouver

Cregg JM, Sidhu SK, Leiras R, Kiehn O. Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice. Nature Neuroscience. 2024;27:716–727. https://doi.org/10.1038/s41593-024-01569-8

Author

Cregg, Jared M. ; Sidhu, Simrandeep K. ; Leiras, Roberto ; Kiehn, Ole. / Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice. In: Nature Neuroscience. 2024 ; Vol. 27. pp. 716–727.

Bibtex

@article{2c3ff331419a40fea0e4a1012e289b6f,
title = "Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice",
abstract = "The basal ganglia are essential for executing motor actions. How the basal ganglia engage spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons are required for turning gait programs, suggesting that turning gaits organized by the basal ganglia are executed via this descending pathway. Performing deep brainstem recordings of Chx10 Gi Ca2+ activity in adult mice, we show that striatal projection neurons initiate turning gaits via a dominant crossed pathway to Chx10 Gi neurons on the contralateral side. Using intersectional viral tracing and cell-type-specific modulation, we uncover the principal basal ganglia–spinal cord pathway for locomotor asymmetries in mice: basal ganglia → pontine reticular nucleus, oral part (PnO) → Chx10 Gi → spinal cord. Modulating the restricted PnO → Chx10 Gi pathway restores turning competence upon striatal damage, suggesting that dysfunction of this pathway may contribute to debilitating turning deficits observed in Parkinson{\textquoteright}s disease. Our results reveal the stratified circuit architecture underlying a critical motor program.",
author = "Cregg, {Jared M.} and Sidhu, {Simrandeep K.} and Roberto Leiras and Ole Kiehn",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",
year = "2024",
doi = "10.1038/s41593-024-01569-8",
language = "English",
volume = "27",
pages = "716–727",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice

AU - Cregg, Jared M.

AU - Sidhu, Simrandeep K.

AU - Leiras, Roberto

AU - Kiehn, Ole

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024

Y1 - 2024

N2 - The basal ganglia are essential for executing motor actions. How the basal ganglia engage spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons are required for turning gait programs, suggesting that turning gaits organized by the basal ganglia are executed via this descending pathway. Performing deep brainstem recordings of Chx10 Gi Ca2+ activity in adult mice, we show that striatal projection neurons initiate turning gaits via a dominant crossed pathway to Chx10 Gi neurons on the contralateral side. Using intersectional viral tracing and cell-type-specific modulation, we uncover the principal basal ganglia–spinal cord pathway for locomotor asymmetries in mice: basal ganglia → pontine reticular nucleus, oral part (PnO) → Chx10 Gi → spinal cord. Modulating the restricted PnO → Chx10 Gi pathway restores turning competence upon striatal damage, suggesting that dysfunction of this pathway may contribute to debilitating turning deficits observed in Parkinson’s disease. Our results reveal the stratified circuit architecture underlying a critical motor program.

AB - The basal ganglia are essential for executing motor actions. How the basal ganglia engage spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons are required for turning gait programs, suggesting that turning gaits organized by the basal ganglia are executed via this descending pathway. Performing deep brainstem recordings of Chx10 Gi Ca2+ activity in adult mice, we show that striatal projection neurons initiate turning gaits via a dominant crossed pathway to Chx10 Gi neurons on the contralateral side. Using intersectional viral tracing and cell-type-specific modulation, we uncover the principal basal ganglia–spinal cord pathway for locomotor asymmetries in mice: basal ganglia → pontine reticular nucleus, oral part (PnO) → Chx10 Gi → spinal cord. Modulating the restricted PnO → Chx10 Gi pathway restores turning competence upon striatal damage, suggesting that dysfunction of this pathway may contribute to debilitating turning deficits observed in Parkinson’s disease. Our results reveal the stratified circuit architecture underlying a critical motor program.

U2 - 10.1038/s41593-024-01569-8

DO - 10.1038/s41593-024-01569-8

M3 - Journal article

C2 - 38347200

AN - SCOPUS:85184929408

VL - 27

SP - 716

EP - 727

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

ER -

ID: 383397266