Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship. / Andersson, Mariam; Kjer, Hans Martin; Rafael-Patino, Jonathan; Pacureanu, Alexandra; Pakkenberg, Bente; Thiran, Jean Philippe; Ptito, Maurice; Bech, Martin; Bjorholm Dahl, Anders; Andersen Dahl, Vedrana; Dyrby, Tim B.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 52, 2020, p. 33649-33659.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Andersson, M, Kjer, HM, Rafael-Patino, J, Pacureanu, A, Pakkenberg, B, Thiran, JP, Ptito, M, Bech, M, Bjorholm Dahl, A, Andersen Dahl, V & Dyrby, TB 2020, 'Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 52, pp. 33649-33659. https://doi.org/10.1073/pnas.2012533117

APA

Andersson, M., Kjer, H. M., Rafael-Patino, J., Pacureanu, A., Pakkenberg, B., Thiran, J. P., Ptito, M., Bech, M., Bjorholm Dahl, A., Andersen Dahl, V., & Dyrby, T. B. (2020). Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship. Proceedings of the National Academy of Sciences of the United States of America, 117(52), 33649-33659. https://doi.org/10.1073/pnas.2012533117

Vancouver

Andersson M, Kjer HM, Rafael-Patino J, Pacureanu A, Pakkenberg B, Thiran JP et al. Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(52):33649-33659. https://doi.org/10.1073/pnas.2012533117

Author

Andersson, Mariam ; Kjer, Hans Martin ; Rafael-Patino, Jonathan ; Pacureanu, Alexandra ; Pakkenberg, Bente ; Thiran, Jean Philippe ; Ptito, Maurice ; Bech, Martin ; Bjorholm Dahl, Anders ; Andersen Dahl, Vedrana ; Dyrby, Tim B. / Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship. In: Proceedings of the National Academy of Sciences of the United States of America. 2020 ; Vol. 117, No. 52. pp. 33649-33659.

Bibtex

@article{bc6aaa3fe140459faae2109905669957,
title = "Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship",
abstract = "Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional (3D) validation. Here, high-resolution, 3D synchrotron X-ray nano-holotomography images of white matter samples from the corpus callosum of a monkey brain reveal that blood vessels, cells, and vacuoles affect axonal diameter and trajectory. Within single axons, we find that the variation in diameter and conduction velocity correlates with the mean diameter, contesting the value of precise diameter determination in larger axons. These complex 3D axon morphologies drive previously reported 2D trends in axon diameter and g-ratio. Furthermore, we find that these morphologies bias the estimates of axon diameter with diffusion magnetic resonance imaging and, ultimately, impact the investigation and formulation of the axon structure-function relationship.",
keywords = "axon morphology, brain, conduction velocity, MRI, myelination",
author = "Mariam Andersson and Kjer, {Hans Martin} and Jonathan Rafael-Patino and Alexandra Pacureanu and Bente Pakkenberg and Thiran, {Jean Philippe} and Maurice Ptito and Martin Bech and {Bjorholm Dahl}, Anders and {Andersen Dahl}, Vedrana and Dyrby, {Tim B.}",
year = "2020",
doi = "10.1073/pnas.2012533117",
language = "English",
volume = "117",
pages = "33649--33659",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "52",

}

RIS

TY - JOUR

T1 - Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship

AU - Andersson, Mariam

AU - Kjer, Hans Martin

AU - Rafael-Patino, Jonathan

AU - Pacureanu, Alexandra

AU - Pakkenberg, Bente

AU - Thiran, Jean Philippe

AU - Ptito, Maurice

AU - Bech, Martin

AU - Bjorholm Dahl, Anders

AU - Andersen Dahl, Vedrana

AU - Dyrby, Tim B.

PY - 2020

Y1 - 2020

N2 - Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional (3D) validation. Here, high-resolution, 3D synchrotron X-ray nano-holotomography images of white matter samples from the corpus callosum of a monkey brain reveal that blood vessels, cells, and vacuoles affect axonal diameter and trajectory. Within single axons, we find that the variation in diameter and conduction velocity correlates with the mean diameter, contesting the value of precise diameter determination in larger axons. These complex 3D axon morphologies drive previously reported 2D trends in axon diameter and g-ratio. Furthermore, we find that these morphologies bias the estimates of axon diameter with diffusion magnetic resonance imaging and, ultimately, impact the investigation and formulation of the axon structure-function relationship.

AB - Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional (3D) validation. Here, high-resolution, 3D synchrotron X-ray nano-holotomography images of white matter samples from the corpus callosum of a monkey brain reveal that blood vessels, cells, and vacuoles affect axonal diameter and trajectory. Within single axons, we find that the variation in diameter and conduction velocity correlates with the mean diameter, contesting the value of precise diameter determination in larger axons. These complex 3D axon morphologies drive previously reported 2D trends in axon diameter and g-ratio. Furthermore, we find that these morphologies bias the estimates of axon diameter with diffusion magnetic resonance imaging and, ultimately, impact the investigation and formulation of the axon structure-function relationship.

KW - axon morphology

KW - brain

KW - conduction velocity

KW - MRI

KW - myelination

U2 - 10.1073/pnas.2012533117

DO - 10.1073/pnas.2012533117

M3 - Journal article

C2 - 33376224

AN - SCOPUS:85099114902

VL - 117

SP - 33649

EP - 33659

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 52

ER -

ID: 255501225