Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose.

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Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose. / Brust, P; Baethmann, A; Gjedde, A; Ermisch, A.

In: Brain Research, Vol. 564, No. 1, 1991, p. 91-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brust, P, Baethmann, A, Gjedde, A & Ermisch, A 1991, 'Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose.', Brain Research, vol. 564, no. 1, pp. 91-6.

APA

Brust, P., Baethmann, A., Gjedde, A., & Ermisch, A. (1991). Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose. Brain Research, 564(1), 91-6.

Vancouver

Brust P, Baethmann A, Gjedde A, Ermisch A. Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose. Brain Research. 1991;564(1):91-6.

Author

Brust, P ; Baethmann, A ; Gjedde, A ; Ermisch, A. / Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose. In: Brain Research. 1991 ; Vol. 564, No. 1. pp. 91-6.

Bibtex

@article{429d1710b31511debc73000ea68e967b,
title = "Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose.",
abstract = "Recent evidence predicts an effect of atrial natriuretic peptide (ANP) on the blood-brain transfer of water. To test this prediction, we measured the blood-brain transfer of water, L-leucine, and D-glucose in 9 brain regions of male rats after intravenous injection of 10 pmol ANP. The peptide elicited an increase of the permeability-surface area (PaS) product of labeled water by 28-108% while the PaS products of leucine and glucose remained unchanged. Cerebral blood flow increased 15-48% while cardiac output and plasma volume in brain did not alter, indicating no change of capillary surface area (CSA). Regionally, the CSA varied from 63 cm2/g (striatum) to 97 cm2/g (colliculi) and the fraction of capillaries contributing to the total vascular volume varied from 29% (olfactory bulb/lobe) to 62% (striatum). The blood-brain barrier (BBB) permeability to water (5.7 micron/s) was an order of magnitude higher than to glucose (0.4 micron/s) or to leucine (0.3 micron/s).",
author = "P Brust and A Baethmann and A Gjedde and A Ermisch",
year = "1991",
language = "English",
volume = "564",
pages = "91--6",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose.

AU - Brust, P

AU - Baethmann, A

AU - Gjedde, A

AU - Ermisch, A

PY - 1991

Y1 - 1991

N2 - Recent evidence predicts an effect of atrial natriuretic peptide (ANP) on the blood-brain transfer of water. To test this prediction, we measured the blood-brain transfer of water, L-leucine, and D-glucose in 9 brain regions of male rats after intravenous injection of 10 pmol ANP. The peptide elicited an increase of the permeability-surface area (PaS) product of labeled water by 28-108% while the PaS products of leucine and glucose remained unchanged. Cerebral blood flow increased 15-48% while cardiac output and plasma volume in brain did not alter, indicating no change of capillary surface area (CSA). Regionally, the CSA varied from 63 cm2/g (striatum) to 97 cm2/g (colliculi) and the fraction of capillaries contributing to the total vascular volume varied from 29% (olfactory bulb/lobe) to 62% (striatum). The blood-brain barrier (BBB) permeability to water (5.7 micron/s) was an order of magnitude higher than to glucose (0.4 micron/s) or to leucine (0.3 micron/s).

AB - Recent evidence predicts an effect of atrial natriuretic peptide (ANP) on the blood-brain transfer of water. To test this prediction, we measured the blood-brain transfer of water, L-leucine, and D-glucose in 9 brain regions of male rats after intravenous injection of 10 pmol ANP. The peptide elicited an increase of the permeability-surface area (PaS) product of labeled water by 28-108% while the PaS products of leucine and glucose remained unchanged. Cerebral blood flow increased 15-48% while cardiac output and plasma volume in brain did not alter, indicating no change of capillary surface area (CSA). Regionally, the CSA varied from 63 cm2/g (striatum) to 97 cm2/g (colliculi) and the fraction of capillaries contributing to the total vascular volume varied from 29% (olfactory bulb/lobe) to 62% (striatum). The blood-brain barrier (BBB) permeability to water (5.7 micron/s) was an order of magnitude higher than to glucose (0.4 micron/s) or to leucine (0.3 micron/s).

M3 - Journal article

C2 - 1838019

VL - 564

SP - 91

EP - 96

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -

ID: 14946800