Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples

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Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. / Tesli, Martin; Koefoed, Pernille; Athanasiu, Lavinia; Mattingsdal, Morten; Gustafsson, Omar; Agartz, Ingrid; Rimol, Lars M; Brown, Andrew; Wirgenes, Katrine V; Smorr, Lisa-Lena; Kähler, Anna K; Werge, Thomas; Mors, Ole; Mellerup, Erling; Jönsson, Erik G; Melle, Ingrid; Morken, Gunnar; Djurovic, Srdjan; Andreassen, Ole A.

In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol. 156, No. 8, 01.12.2011, p. 969-74.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tesli, M, Koefoed, P, Athanasiu, L, Mattingsdal, M, Gustafsson, O, Agartz, I, Rimol, LM, Brown, A, Wirgenes, KV, Smorr, L-L, Kähler, AK, Werge, T, Mors, O, Mellerup, E, Jönsson, EG, Melle, I, Morken, G, Djurovic, S & Andreassen, OA 2011, 'Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 156, no. 8, pp. 969-74. https://doi.org/10.1002/ajmg.b.31244

APA

Tesli, M., Koefoed, P., Athanasiu, L., Mattingsdal, M., Gustafsson, O., Agartz, I., Rimol, L. M., Brown, A., Wirgenes, K. V., Smorr, L-L., Kähler, A. K., Werge, T., Mors, O., Mellerup, E., Jönsson, E. G., Melle, I., Morken, G., Djurovic, S., & Andreassen, O. A. (2011). Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 156(8), 969-74. https://doi.org/10.1002/ajmg.b.31244

Vancouver

Tesli M, Koefoed P, Athanasiu L, Mattingsdal M, Gustafsson O, Agartz I et al. Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2011 Dec 1;156(8):969-74. https://doi.org/10.1002/ajmg.b.31244

Author

Tesli, Martin ; Koefoed, Pernille ; Athanasiu, Lavinia ; Mattingsdal, Morten ; Gustafsson, Omar ; Agartz, Ingrid ; Rimol, Lars M ; Brown, Andrew ; Wirgenes, Katrine V ; Smorr, Lisa-Lena ; Kähler, Anna K ; Werge, Thomas ; Mors, Ole ; Mellerup, Erling ; Jönsson, Erik G ; Melle, Ingrid ; Morken, Gunnar ; Djurovic, Srdjan ; Andreassen, Ole A. / Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2011 ; Vol. 156, No. 8. pp. 969-74.

Bibtex

@article{ee90d7b3fd0949f39d5a3706807275fc,
title = "Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples",
abstract = "Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case–control sample (N¿=¿854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case–control sample (N¿=¿1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N¿=¿435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N¿=¿1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P¿=¿0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P¿=¿0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case–control sample (N¿=¿1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved. {\textcopyright} 2011 Wiley Periodicals, Inc.",
author = "Martin Tesli and Pernille Koefoed and Lavinia Athanasiu and Morten Mattingsdal and Omar Gustafsson and Ingrid Agartz and Rimol, {Lars M} and Andrew Brown and Wirgenes, {Katrine V} and Lisa-Lena Smorr and K{\"a}hler, {Anna K} and Thomas Werge and Ole Mors and Erling Mellerup and J{\"o}nsson, {Erik G} and Ingrid Melle and Gunnar Morken and Srdjan Djurovic and Andreassen, {Ole A}",
note = "Copyright {\textcopyright} 2011 Wiley Periodicals, Inc.",
year = "2011",
month = dec,
day = "1",
doi = "10.1002/ajmg.b.31244",
language = "English",
volume = "156",
pages = "969--74",
journal = "American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "JohnWiley & Sons, Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples

AU - Tesli, Martin

AU - Koefoed, Pernille

AU - Athanasiu, Lavinia

AU - Mattingsdal, Morten

AU - Gustafsson, Omar

AU - Agartz, Ingrid

AU - Rimol, Lars M

AU - Brown, Andrew

AU - Wirgenes, Katrine V

AU - Smorr, Lisa-Lena

AU - Kähler, Anna K

AU - Werge, Thomas

AU - Mors, Ole

AU - Mellerup, Erling

AU - Jönsson, Erik G

AU - Melle, Ingrid

AU - Morken, Gunnar

AU - Djurovic, Srdjan

AU - Andreassen, Ole A

N1 - Copyright © 2011 Wiley Periodicals, Inc.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case–control sample (N¿=¿854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case–control sample (N¿=¿1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N¿=¿435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N¿=¿1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P¿=¿0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P¿=¿0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case–control sample (N¿=¿1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved. © 2011 Wiley Periodicals, Inc.

AB - Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case–control sample (N¿=¿854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case–control sample (N¿=¿1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N¿=¿435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N¿=¿1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P¿=¿0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P¿=¿0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case–control sample (N¿=¿1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved. © 2011 Wiley Periodicals, Inc.

U2 - 10.1002/ajmg.b.31244

DO - 10.1002/ajmg.b.31244

M3 - Journal article

C2 - 21972176

VL - 156

SP - 969

EP - 974

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 8

ER -

ID: 35128489