Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup. / Sørensen, Daniel Mosgaard; Bostock, Hugh; Ballegaard, Martin; Fuglsang-Frederiksen, Anders; Graffe, Carolina Canillo; Grötting, Arnstein; Jones, Kelvin; Kallio, Mika; Krarup, Christian; Krøigård, Thomas; Lupescu, Tudor; Maitland, Stuart; Moldovan, Mihai; Nilsen, Kristian Bernhard; Pugdahl, Kirsten; Santos, Miguel Oliveira; Themistocleous, Andreas Constantinos; Zlateva, Suzana Slavica; Ööpik, Merle; Tankisi, Hatice.

In: Neurophysiologie Clinique, Vol. 52, No. 2, 2022, p. 157-169.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sørensen, DM, Bostock, H, Ballegaard, M, Fuglsang-Frederiksen, A, Graffe, CC, Grötting, A, Jones, K, Kallio, M, Krarup, C, Krøigård, T, Lupescu, T, Maitland, S, Moldovan, M, Nilsen, KB, Pugdahl, K, Santos, MO, Themistocleous, AC, Zlateva, SS, Ööpik, M & Tankisi, H 2022, 'Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup', Neurophysiologie Clinique, vol. 52, no. 2, pp. 157-169. https://doi.org/10.1016/j.neucli.2021.11.002

APA

Sørensen, D. M., Bostock, H., Ballegaard, M., Fuglsang-Frederiksen, A., Graffe, C. C., Grötting, A., Jones, K., Kallio, M., Krarup, C., Krøigård, T., Lupescu, T., Maitland, S., Moldovan, M., Nilsen, K. B., Pugdahl, K., Santos, M. O., Themistocleous, A. C., Zlateva, S. S., Ööpik, M., & Tankisi, H. (2022). Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup. Neurophysiologie Clinique, 52(2), 157-169. https://doi.org/10.1016/j.neucli.2021.11.002

Vancouver

Sørensen DM, Bostock H, Ballegaard M, Fuglsang-Frederiksen A, Graffe CC, Grötting A et al. Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup. Neurophysiologie Clinique. 2022;52(2):157-169. https://doi.org/10.1016/j.neucli.2021.11.002

Author

Sørensen, Daniel Mosgaard ; Bostock, Hugh ; Ballegaard, Martin ; Fuglsang-Frederiksen, Anders ; Graffe, Carolina Canillo ; Grötting, Arnstein ; Jones, Kelvin ; Kallio, Mika ; Krarup, Christian ; Krøigård, Thomas ; Lupescu, Tudor ; Maitland, Stuart ; Moldovan, Mihai ; Nilsen, Kristian Bernhard ; Pugdahl, Kirsten ; Santos, Miguel Oliveira ; Themistocleous, Andreas Constantinos ; Zlateva, Suzana Slavica ; Ööpik, Merle ; Tankisi, Hatice. / Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup. In: Neurophysiologie Clinique. 2022 ; Vol. 52, No. 2. pp. 157-169.

Bibtex

@article{065f5c5acf8f4e948a8b2a43c7845cde,

title = "Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup",

abstract = "Objective: To assess the inter-rater reliability of MScanFit MUNE using a “Round Robin” research design. Methods: Twelve raters from different centres examined six healthy study participants over two days. Median, ulnar and common peroneal nerves were stimulated, and compound muscle action potential (CMAP)-scans were recorded from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and anterior tibial (TA) muscles respectively. From this we calculated the Motor Unit Number Estimation (MUNE) and “A50”, a motor unit size parameter. As statistical analysis we used the measures Limits of Agreement (LOA) and Coefficient of Variation (COV). Study participants scored their perception of pain from the examinations on a rating scale from 0 (no pain) to 10 (unbearable pain). Results: Before this study, 41.6% of the raters had performed MScanFit less than five times. The mean MUNE-values were: 99.6 (APB), 131.4 (ADM) and 126.2 (TA), with LOA: 19.5 (APB), 29.8 (ADM) and 20.7 (TA), and COV: 13.4 (APB), 6.3 (ADM) and 5.6 (TA). MUNE-values correlated to CMAP max amplitudes (R2-values were: 0.463 (APB) (p<0.001), 0.421 (ADM) (p<0.001) and 0.645 (TA) (p<0.001)). The average perception of pain was 4. Discussion: MScanFit indicates a high level of inter-rater reliability, even with only limited rater experience and is overall reasonably well tolerated by patients. These results may indicate MScanFit as a reliable MUNE method with potential as a biomarker in drug trials.",

keywords = "Inter-rater variability, Motor neurone disease, Motor unit number estimation, MScanFit MUNE, Neurodegenerative Disease",

author = "S{\o}rensen, {Daniel Mosgaard} and Hugh Bostock and Martin Ballegaard and Anders Fuglsang-Frederiksen and Graffe, {Carolina Canillo} and Arnstein Gr{\"o}tting and Kelvin Jones and Mika Kallio and Christian Krarup and Thomas Kr{\o}ig{\aa}rd and Tudor Lupescu and Stuart Maitland and Mihai Moldovan and Nilsen, {Kristian Bernhard} and Kirsten Pugdahl and Santos, {Miguel Oliveira} and Themistocleous, {Andreas Constantinos} and Zlateva, {Suzana Slavica} and Merle {\"O}{\"o}pik and Hatice Tankisi",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Masson SAS",

year = "2022",

doi = "10.1016/j.neucli.2021.11.002",

language = "English",

volume = "52",

pages = "157--169",

journal = "Neurophysiologie Clinique",

issn = "0987-7053",

publisher = "Elsevier Masson",

number = "2",

}

RIS

TY - JOUR

T1 - Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup

AU - Sørensen, Daniel Mosgaard

AU - Bostock, Hugh

AU - Ballegaard, Martin

AU - Fuglsang-Frederiksen, Anders

AU - Graffe, Carolina Canillo

AU - Grötting, Arnstein

AU - Jones, Kelvin

AU - Kallio, Mika

AU - Krarup, Christian

AU - Krøigård, Thomas

AU - Lupescu, Tudor

AU - Maitland, Stuart

AU - Moldovan, Mihai

AU - Nilsen, Kristian Bernhard

AU - Pugdahl, Kirsten

AU - Santos, Miguel Oliveira

AU - Themistocleous, Andreas Constantinos

AU - Zlateva, Suzana Slavica

AU - Ööpik, Merle

AU - Tankisi, Hatice

PY - 2022

Y1 - 2022

N2 - Objective: To assess the inter-rater reliability of MScanFit MUNE using a “Round Robin” research design. Methods: Twelve raters from different centres examined six healthy study participants over two days. Median, ulnar and common peroneal nerves were stimulated, and compound muscle action potential (CMAP)-scans were recorded from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and anterior tibial (TA) muscles respectively. From this we calculated the Motor Unit Number Estimation (MUNE) and “A50”, a motor unit size parameter. As statistical analysis we used the measures Limits of Agreement (LOA) and Coefficient of Variation (COV). Study participants scored their perception of pain from the examinations on a rating scale from 0 (no pain) to 10 (unbearable pain). Results: Before this study, 41.6% of the raters had performed MScanFit less than five times. The mean MUNE-values were: 99.6 (APB), 131.4 (ADM) and 126.2 (TA), with LOA: 19.5 (APB), 29.8 (ADM) and 20.7 (TA), and COV: 13.4 (APB), 6.3 (ADM) and 5.6 (TA). MUNE-values correlated to CMAP max amplitudes (R2-values were: 0.463 (APB) (p<0.001), 0.421 (ADM) (p<0.001) and 0.645 (TA) (p<0.001)). The average perception of pain was 4. Discussion: MScanFit indicates a high level of inter-rater reliability, even with only limited rater experience and is overall reasonably well tolerated by patients. These results may indicate MScanFit as a reliable MUNE method with potential as a biomarker in drug trials.

AB - Objective: To assess the inter-rater reliability of MScanFit MUNE using a “Round Robin” research design. Methods: Twelve raters from different centres examined six healthy study participants over two days. Median, ulnar and common peroneal nerves were stimulated, and compound muscle action potential (CMAP)-scans were recorded from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and anterior tibial (TA) muscles respectively. From this we calculated the Motor Unit Number Estimation (MUNE) and “A50”, a motor unit size parameter. As statistical analysis we used the measures Limits of Agreement (LOA) and Coefficient of Variation (COV). Study participants scored their perception of pain from the examinations on a rating scale from 0 (no pain) to 10 (unbearable pain). Results: Before this study, 41.6% of the raters had performed MScanFit less than five times. The mean MUNE-values were: 99.6 (APB), 131.4 (ADM) and 126.2 (TA), with LOA: 19.5 (APB), 29.8 (ADM) and 20.7 (TA), and COV: 13.4 (APB), 6.3 (ADM) and 5.6 (TA). MUNE-values correlated to CMAP max amplitudes (R2-values were: 0.463 (APB) (p<0.001), 0.421 (ADM) (p<0.001) and 0.645 (TA) (p<0.001)). The average perception of pain was 4. Discussion: MScanFit indicates a high level of inter-rater reliability, even with only limited rater experience and is overall reasonably well tolerated by patients. These results may indicate MScanFit as a reliable MUNE method with potential as a biomarker in drug trials.

KW - Inter-rater variability

KW - Motor neurone disease

KW - Motor unit number estimation

KW - MScanFit MUNE

KW - Neurodegenerative Disease

U2 - 10.1016/j.neucli.2021.11.002

DO - 10.1016/j.neucli.2021.11.002

M3 - Journal article

C2 - 34906430

AN - SCOPUS:85121008238

VL - 52

SP - 157

EP - 169

JO - Neurophysiologie Clinique

JF - Neurophysiologie Clinique

SN - 0987-7053

IS - 2

ER -

ID: 287705557

Department of Neuroscience