Analysis of time and space invariance of BOLD responses in the rat visual system
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Analysis of time and space invariance of BOLD responses in the rat visual system. / Bailey, Christopher; Sanganahalli, Basavaraju G; Herman, Peter; Blumenfeld, Hal; Gjedde, Albert; Hyder, Fahmeed.
In: Cerebral Cortex, Vol. 23, No. 1, 01.2013, p. 210-23.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Analysis of time and space invariance of BOLD responses in the rat visual system
AU - Bailey, Christopher
AU - Sanganahalli, Basavaraju G
AU - Herman, Peter
AU - Blumenfeld, Hal
AU - Gjedde, Albert
AU - Hyder, Fahmeed
PY - 2013/1
Y1 - 2013/1
N2 - Neuroimaging studies of functional magnetic resonance imaging (fMRI) and electrophysiology provide the linkage between neural activity and the blood oxygenation level-dependent (BOLD) response. Here, BOLD responses to light flashes were imaged at 11.7T and compared with neural recordings from superior colliculus (SC) and primary visual cortex (V1) in rat brain--regions with different basal blood flow and energy demand. Our goal was to assess neurovascular coupling in V1 and SC as reflected by temporal/spatial variances of impulse response functions (IRFs) and assess, if any, implications for general linear modeling (GLM) of BOLD responses. Light flashes induced high magnitude neural/BOLD responses reproducibly from both regions. However, neural/BOLD responses from SC and V1 were markedly different. SC signals followed the boxcar shape of the stimulation paradigm at all flash rates, whereas V1 signals were characterized by onset/offset transients that exhibited different flash rate dependencies. We find that IRF(SC) is generally time-invariant across wider flash rate range compared with IRF(V1), whereas IRF(SC) and IRF(V1) are both space invariant. These results illustrate the importance of measured neural signals for interpretation of fMRI by showing that GLM of BOLD responses may lead to misinterpretation of neural activity in some cases.
AB - Neuroimaging studies of functional magnetic resonance imaging (fMRI) and electrophysiology provide the linkage between neural activity and the blood oxygenation level-dependent (BOLD) response. Here, BOLD responses to light flashes were imaged at 11.7T and compared with neural recordings from superior colliculus (SC) and primary visual cortex (V1) in rat brain--regions with different basal blood flow and energy demand. Our goal was to assess neurovascular coupling in V1 and SC as reflected by temporal/spatial variances of impulse response functions (IRFs) and assess, if any, implications for general linear modeling (GLM) of BOLD responses. Light flashes induced high magnitude neural/BOLD responses reproducibly from both regions. However, neural/BOLD responses from SC and V1 were markedly different. SC signals followed the boxcar shape of the stimulation paradigm at all flash rates, whereas V1 signals were characterized by onset/offset transients that exhibited different flash rate dependencies. We find that IRF(SC) is generally time-invariant across wider flash rate range compared with IRF(V1), whereas IRF(SC) and IRF(V1) are both space invariant. These results illustrate the importance of measured neural signals for interpretation of fMRI by showing that GLM of BOLD responses may lead to misinterpretation of neural activity in some cases.
U2 - 10.1093/cercor/bhs008
DO - 10.1093/cercor/bhs008
M3 - Journal article
C2 - 22298731
VL - 23
SP - 210
EP - 223
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 1
ER -
ID: 44913711