Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats. / Spulber, S.; Moldovan, Mihai; Oprica, M.; Aronsson, A.F.; Post, C.; Winblad, B.; Schultzberg, M.

In: NeuroReport, Vol. 16, No. 1, 2005, p. 69-72.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Spulber, S, Moldovan, M, Oprica, M, Aronsson, AF, Post, C, Winblad, B & Schultzberg, M 2005, 'Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats', NeuroReport, vol. 16, no. 1, pp. 69-72.

APA

Spulber, S., Moldovan, M., Oprica, M., Aronsson, A. F., Post, C., Winblad, B., & Schultzberg, M. (2005). Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats. NeuroReport, 16(1), 69-72.

Vancouver

Spulber S, Moldovan M, Oprica M, Aronsson AF, Post C, Winblad B et al. Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats. NeuroReport. 2005;16(1):69-72.

Author

Spulber, S. ; Moldovan, Mihai ; Oprica, M. ; Aronsson, A.F. ; Post, C. ; Winblad, B. ; Schultzberg, M. / Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats. In: NeuroReport. 2005 ; Vol. 16, No. 1. pp. 69-72.

Bibtex

@article{100ac3e074c211dbbee902004c4f4f50,
title = "Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats",
abstract = "A key pathological event during cerebral ischemia is the excitotoxic release of glutamate. We have shown previously that alpha-melanocyte-stimulating hormone (alpha-MSH) enhances the hypothermia induced by kainic acid. We have investigated the effects of systemic administration of alpha-MSH on four-vessel occlusion forebrain ischemia on core temperature (CT) and brain temperature (BT), respectively. After 10 min cerebral ischemia, BT was lower in alpha-MSH- than in saline-injected animals. After 10 min reperfusion, both CT and BT were lower than the corresponding pre-ischemic levels after injection of alpha-MSH. alpha-MSH did not influence CT or BT in sham-operated rats. The alpha-MSH-induced hypothermia and its potentiation of reduction in BT during global cerebral ischemia, may contribute to neuroprotective effects of alpha-MSH.",
author = "S. Spulber and Mihai Moldovan and M. Oprica and A.F. Aronsson and C. Post and B. Winblad and M. Schultzberg",
note = "Keywords: Animals; Body Temperature; Brain; Ischemic Attack, Transient; Kinetics; Male; Rats; Rats, Sprague-Dawley; Reference Values; alpha-MSH",
year = "2005",
language = "English",
volume = "16",
pages = "69--72",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams & Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats

AU - Spulber, S.

AU - Moldovan, Mihai

AU - Oprica, M.

AU - Aronsson, A.F.

AU - Post, C.

AU - Winblad, B.

AU - Schultzberg, M.

N1 - Keywords: Animals; Body Temperature; Brain; Ischemic Attack, Transient; Kinetics; Male; Rats; Rats, Sprague-Dawley; Reference Values; alpha-MSH

PY - 2005

Y1 - 2005

N2 - A key pathological event during cerebral ischemia is the excitotoxic release of glutamate. We have shown previously that alpha-melanocyte-stimulating hormone (alpha-MSH) enhances the hypothermia induced by kainic acid. We have investigated the effects of systemic administration of alpha-MSH on four-vessel occlusion forebrain ischemia on core temperature (CT) and brain temperature (BT), respectively. After 10 min cerebral ischemia, BT was lower in alpha-MSH- than in saline-injected animals. After 10 min reperfusion, both CT and BT were lower than the corresponding pre-ischemic levels after injection of alpha-MSH. alpha-MSH did not influence CT or BT in sham-operated rats. The alpha-MSH-induced hypothermia and its potentiation of reduction in BT during global cerebral ischemia, may contribute to neuroprotective effects of alpha-MSH.

AB - A key pathological event during cerebral ischemia is the excitotoxic release of glutamate. We have shown previously that alpha-melanocyte-stimulating hormone (alpha-MSH) enhances the hypothermia induced by kainic acid. We have investigated the effects of systemic administration of alpha-MSH on four-vessel occlusion forebrain ischemia on core temperature (CT) and brain temperature (BT), respectively. After 10 min cerebral ischemia, BT was lower in alpha-MSH- than in saline-injected animals. After 10 min reperfusion, both CT and BT were lower than the corresponding pre-ischemic levels after injection of alpha-MSH. alpha-MSH did not influence CT or BT in sham-operated rats. The alpha-MSH-induced hypothermia and its potentiation of reduction in BT during global cerebral ischemia, may contribute to neuroprotective effects of alpha-MSH.

M3 - Journal article

C2 - 15618893

VL - 16

SP - 69

EP - 72

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 1

ER -

ID: 68793