A volumetric screening procedure for the Göttingen minipig brain.
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
A volumetric screening procedure for the Göttingen minipig brain. / Jelsing, J; Olsen, Aage K.; Cumming, P; Gjedde, A; Hansen, A K; Arnfred, S; Hemmingsen, R; Pakkenberg, Bente.
In: Experimental Brain Research, Vol. 162, No. 4, 2005, p. 428-35.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A volumetric screening procedure for the Göttingen minipig brain.
AU - Jelsing, J
AU - Olsen, Aage K.
AU - Cumming, P
AU - Gjedde, A
AU - Hansen, A K
AU - Arnfred, S
AU - Hemmingsen, R
AU - Pakkenberg, Bente
PY - 2005
Y1 - 2005
N2 - A screening procedure was developed to provide quantitative estimates of structural parameters, regional volumes and neuron number, in a neurotoxicologic study of the Göttingen minipig brain. The study material consisted of normal controls and brains collected from young minipigs which had been exposed in utero to the mitotic inhibitor methylazoxymethanol acetate (MAM). Based on stereological principles and systematic sampling techniques, volumetric data from pre-selected regions of the pig brain was obtained using Cavalieri's principles and point-counting. Secondarily, estimates of total hemispheric neocortical cell numbers were obtained from pre-selected groups to test the potential effect of MAM on neuron number. No significant differences were observed in volume of the pre-selected regions of MAM intoxicated pigs nor in estimates of total neocortical neuron number.
AB - A screening procedure was developed to provide quantitative estimates of structural parameters, regional volumes and neuron number, in a neurotoxicologic study of the Göttingen minipig brain. The study material consisted of normal controls and brains collected from young minipigs which had been exposed in utero to the mitotic inhibitor methylazoxymethanol acetate (MAM). Based on stereological principles and systematic sampling techniques, volumetric data from pre-selected regions of the pig brain was obtained using Cavalieri's principles and point-counting. Secondarily, estimates of total hemispheric neocortical cell numbers were obtained from pre-selected groups to test the potential effect of MAM on neuron number. No significant differences were observed in volume of the pre-selected regions of MAM intoxicated pigs nor in estimates of total neocortical neuron number.
U2 - 10.1007/s00221-004-2026-7
DO - 10.1007/s00221-004-2026-7
M3 - Journal article
C2 - 15668795
VL - 162
SP - 428
EP - 435
JO - Experimental Brain Research
JF - Experimental Brain Research
SN - 0014-4819
IS - 4
ER -
ID: 14946677