A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition. / Xu, Ruodan; Pankratova, Stanislava; Christiansen, Søren Hofman Oliveira; Woldbye, David Paul Drucker; Højland, Anne; Bock, Elisabeth Marianne; Berezin, Vladimir.

In: Neurochemical Research, Vol. 38, No. 12, 2013, p. 2550-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Xu, R, Pankratova, S, Christiansen, SHO, Woldbye, DPD, Højland, A, Bock, EM & Berezin, V 2013, 'A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition', Neurochemical Research, vol. 38, no. 12, pp. 2550-8. https://doi.org/10.1007/s11064-013-1166-1

APA

Xu, R., Pankratova, S., Christiansen, S. H. O., Woldbye, D. P. D., Højland, A., Bock, E. M., & Berezin, V. (2013). A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition. Neurochemical Research, 38(12), 2550-8. https://doi.org/10.1007/s11064-013-1166-1

Vancouver

Xu R, Pankratova S, Christiansen SHO, Woldbye DPD, Højland A, Bock EM et al. A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition. Neurochemical Research. 2013;38(12):2550-8. https://doi.org/10.1007/s11064-013-1166-1

Author

Xu, Ruodan ; Pankratova, Stanislava ; Christiansen, Søren Hofman Oliveira ; Woldbye, David Paul Drucker ; Højland, Anne ; Bock, Elisabeth Marianne ; Berezin, Vladimir. / A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition. In: Neurochemical Research. 2013 ; Vol. 38, No. 12. pp. 2550-8.

Bibtex

@article{63b1aa509990478b89a1188458ad3b03,
title = "A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition",
abstract = "rbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation. ",
author = "Ruodan Xu and Stanislava Pankratova and Christiansen, {S{\o}ren Hofman Oliveira} and Woldbye, {David Paul Drucker} and Anne H{\o}jland and Bock, {Elisabeth Marianne} and Vladimir Berezin",
year = "2013",
doi = "10.1007/s11064-013-1166-1",
language = "English",
volume = "38",
pages = "2550--8",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

AU - Xu, Ruodan

AU - Pankratova, Stanislava

AU - Christiansen, Søren Hofman Oliveira

AU - Woldbye, David Paul Drucker

AU - Højland, Anne

AU - Bock, Elisabeth Marianne

AU - Berezin, Vladimir

PY - 2013

Y1 - 2013

N2 - rbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.

AB - rbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.

U2 - 10.1007/s11064-013-1166-1

DO - 10.1007/s11064-013-1166-1

M3 - Journal article

C2 - 24132641

VL - 38

SP - 2550

EP - 2558

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 12

ER -

ID: 105608139