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A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins. / Chae, Pil Seok; Rasmussen, Søren G F; Rana, Rohini R; Gotfryd, Kamil; Kruse, Andrew C; Manglik, Aashish; Cho, Kyung Ho; Nurva, Shailika; Gether, Ulrik; Guan, Lan; Loland, Claus J; Byrne, Bernadette; Kobilka, Brian K; Gellman, Samuel H.
In:
Chemistry: A European Journal, Vol. 18, No. 31, 27.07.2012, p. 9485-90.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Chae, PS
, Rasmussen, SGF, Rana, RR, Gotfryd, K, Kruse, AC, Manglik, A, Cho, KH, Nurva, S
, Gether, U, Guan, L
, Loland, CJ, Byrne, B, Kobilka, BK & Gellman, SH 2012, '
A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins',
Chemistry: A European Journal, vol. 18, no. 31, pp. 9485-90.
https://doi.org/10.1002/chem.201200069APA
Chae, P. S.
, Rasmussen, S. G. F., Rana, R. R., Gotfryd, K., Kruse, A. C., Manglik, A., Cho, K. H., Nurva, S.
, Gether, U., Guan, L.
, Loland, C. J., Byrne, B., Kobilka, B. K., & Gellman, S. H. (2012).
A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins.
Chemistry: A European Journal,
18(31), 9485-90.
https://doi.org/10.1002/chem.201200069Vancouver
Chae PS
, Rasmussen SGF, Rana RR, Gotfryd K, Kruse AC, Manglik A et al.
A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins.
Chemistry: A European Journal. 2012 Jul 27;18(31):9485-90.
https://doi.org/10.1002/chem.201200069Author
Chae, Pil Seok ; Rasmussen, Søren G F ; Rana, Rohini R ; Gotfryd, Kamil ; Kruse, Andrew C ; Manglik, Aashish ; Cho, Kyung Ho ; Nurva, Shailika ; Gether, Ulrik ; Guan, Lan ; Loland, Claus J ; Byrne, Bernadette ; Kobilka, Brian K ; Gellman, Samuel H. / A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins. In: Chemistry: A European Journal. 2012 ; Vol. 18, No. 31. pp. 9485-90.
Bibtex
@article{d12e3245383447c79bb2789cce0f559e,
title = "A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins",
abstract = "Non-traditional amphiphiles: Conferring aqueous solubility on membrane proteins generally requires the use of a detergent or other amphiphilic agent. A new class of amphiphiles was synthesized, based on steroidal lipophilic groups, and evaluated with several membrane proteins. The results show that the new amphiphile, {"}glyco-diosgenin{"} (GDN; see figure), confers enhanced stability to a variety of membrane proteins in solution relative to popular conventional detergents, such as dodecylmaltoside (DDM).",
author = "Chae, {Pil Seok} and Rasmussen, {S{\o}ren G F} and Rana, {Rohini R} and Kamil Gotfryd and Kruse, {Andrew C} and Aashish Manglik and Cho, {Kyung Ho} and Shailika Nurva and Ulrik Gether and Lan Guan and Loland, {Claus J} and Bernadette Byrne and Kobilka, {Brian K} and Gellman, {Samuel H}",
note = "Copyright {\textcopyright} 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2012",
month = jul,
day = "27",
doi = "10.1002/chem.201200069",
language = "English",
volume = "18",
pages = "9485--90",
journal = "Chemistry: A European Journal",
issn = "0947-6539",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "31",
}
RIS
TY - JOUR
T1 - A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
AU - Chae, Pil Seok
AU - Rasmussen, Søren G F
AU - Rana, Rohini R
AU - Gotfryd, Kamil
AU - Kruse, Andrew C
AU - Manglik, Aashish
AU - Cho, Kyung Ho
AU - Nurva, Shailika
AU - Gether, Ulrik
AU - Guan, Lan
AU - Loland, Claus J
AU - Byrne, Bernadette
AU - Kobilka, Brian K
AU - Gellman, Samuel H
N1 - Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2012/7/27
Y1 - 2012/7/27
N2 - Non-traditional amphiphiles: Conferring aqueous solubility on membrane proteins generally requires the use of a detergent or other amphiphilic agent. A new class of amphiphiles was synthesized, based on steroidal lipophilic groups, and evaluated with several membrane proteins. The results show that the new amphiphile, "glyco-diosgenin" (GDN; see figure), confers enhanced stability to a variety of membrane proteins in solution relative to popular conventional detergents, such as dodecylmaltoside (DDM).
AB - Non-traditional amphiphiles: Conferring aqueous solubility on membrane proteins generally requires the use of a detergent or other amphiphilic agent. A new class of amphiphiles was synthesized, based on steroidal lipophilic groups, and evaluated with several membrane proteins. The results show that the new amphiphile, "glyco-diosgenin" (GDN; see figure), confers enhanced stability to a variety of membrane proteins in solution relative to popular conventional detergents, such as dodecylmaltoside (DDM).
U2 - 10.1002/chem.201200069
DO - 10.1002/chem.201200069
M3 - Journal article
C2 - 22730191
VL - 18
SP - 9485
EP - 9490
JO - Chemistry: A European Journal
JF - Chemistry: A European Journal
SN - 0947-6539
IS - 31
ER -
