A method to assess the default EEG macrostate and its reactivity to stimulation
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A method to assess the default EEG macrostate and its reactivity to stimulation. / Serban, Cosmin Andrei; Barborica, Andrei; Roceanu, Adina Maria; Mindruta, Ioana; Ciurea, Jan; Pâslaru, Alexandru C.; Zăgrean, Ana Maria; Zăgrean, Leon; Moldovan, Mihai.
In: Clinical Neurophysiology, Vol. 134, 2022, p. 50-64.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A method to assess the default EEG macrostate and its reactivity to stimulation
AU - Serban, Cosmin Andrei
AU - Barborica, Andrei
AU - Roceanu, Adina Maria
AU - Mindruta, Ioana
AU - Ciurea, Jan
AU - Pâslaru, Alexandru C.
AU - Zăgrean, Ana Maria
AU - Zăgrean, Leon
AU - Moldovan, Mihai
N1 - Publisher Copyright: © 2021 International Federation of Clinical Neurophysiology
PY - 2022
Y1 - 2022
N2 - Objective: The default mode network (DMN) is deactivated by stimulation. We aimed to assess the DMN reactivity impairment by routine EEG recordings in stroke patients with impaired consciousness. Methods: Binocular light flashes were delivered at 1 Hz in 1-minute epochs, following a 1-minute baseline (PRE). The EEG was decomposed in a series of binary oscillatory macrostates by topographic spectral clustering. The most deactivated macrostate was labeled the default EEG macrostate (DEM). Its reactivity (DER) was quantified as the decrease in DEM occurrence probability during stimulation. A normalized DER index (DERI) was calculated as DER/PRE. The measures were compared between 14 healthy controls and 32 comatose patients under EEG monitoring following an acute stroke. Results: The DEM was mapped to the posterior DMN hubs. In the patients, these DEM source dipoles were 3–4 times less frequent and were associated with an increased theta activity. Even in a reduced 6-channel montage, a DER below 6.26% corresponding to a DERI below 0.25 could discriminate the patients with sensitivity and specificity well above 80%. Conclusion: The method detected the DMN impairment in post-stroke coma patients. Significance: The DEM and its reactivity to stimulation could be useful to monitor the DMN function at bedside.
AB - Objective: The default mode network (DMN) is deactivated by stimulation. We aimed to assess the DMN reactivity impairment by routine EEG recordings in stroke patients with impaired consciousness. Methods: Binocular light flashes were delivered at 1 Hz in 1-minute epochs, following a 1-minute baseline (PRE). The EEG was decomposed in a series of binary oscillatory macrostates by topographic spectral clustering. The most deactivated macrostate was labeled the default EEG macrostate (DEM). Its reactivity (DER) was quantified as the decrease in DEM occurrence probability during stimulation. A normalized DER index (DERI) was calculated as DER/PRE. The measures were compared between 14 healthy controls and 32 comatose patients under EEG monitoring following an acute stroke. Results: The DEM was mapped to the posterior DMN hubs. In the patients, these DEM source dipoles were 3–4 times less frequent and were associated with an increased theta activity. Even in a reduced 6-channel montage, a DER below 6.26% corresponding to a DERI below 0.25 could discriminate the patients with sensitivity and specificity well above 80%. Conclusion: The method detected the DMN impairment in post-stroke coma patients. Significance: The DEM and its reactivity to stimulation could be useful to monitor the DMN function at bedside.
KW - Default mode network
KW - EEG reactivity
KW - Macrostate
KW - Reactivity index
U2 - 10.1016/j.clinph.2021.12.002
DO - 10.1016/j.clinph.2021.12.002
M3 - Journal article
C2 - 34973517
AN - SCOPUS:85121927449
VL - 134
SP - 50
EP - 64
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
ER -
ID: 289236583